Universität zu Köln

Brosseron, Frederic, Kleemann, Kilian, Kolbe, Carl-Christian, Santarelli, Francesco, Castro-Gomez, Sergio ORCID: 0000-0002-1581-474X, Tacik, Pawel, Latz, Eicke, Jessen, Frank and Heneka, Michael T. . Interrelations of Alzheimer ' s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation. J. Neurochem.. HOBOKEN: WILEY. ISSN 1471-4159

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Abstract

There is growing evidence that promising biomarkers of inflammation in Alzheimer ' s disease (AD) and other neurodegenerative diseases correlate strongest to levels of tau or neurofilament, indicating an inflammatory response to neuronal damage or death. To test this hypothesis, we investigated three AD candidate markers (ferritin, fatty acid binding protein 3 (FABP-3), and neurogranin) in interrelation to established AD and inflammatory protein markers. We further aimed to determine if such interrelations would be evident in pathological subjects only or also under non-pathological circumstances. Cerebrospinal fluid levels of the three proteins were quantified in samples from the University Clinic of Bonn (UKB) Department of Neurodegenerative Diseases & Geriatric Psychiatry, Germany. Data were analyzed based on clinical or biomarker-defined stratification of subjects with adjustment for covariates age, sex, andAPOEstatus. Levels of ferritin, FABP-3 and neurogranin were elevated in subjects with pathological levels of t-tau independent of beta-amyloid status. The three markers correlated with each other, tau isoforms, age, and those inflammatory markers previously described as related to neurodegeneration, predominantly sTREM2, macrophage migration inhibitory factor, soluble vascular endothelial growth factor receptor, soluble vascular cell adhesion molecule 1 (sVCAM-1), and C1q. These interrelations existed in subjects with pathological and sub-pathological tau levels, in particular for FABP-3 and neurogranin. Relations to ferritin were independent of absolute levels of tau, too, but showed differing trajectories between pathological and non-pathological subjects. A specific set of inflammatory markers is highly related to markers of neuronal damage such as tau, neurogranin, or FABP-3. These proteins could be used as readouts of the inflammatory response during the neurodegeneration phase of AD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Brosseron, Frederic UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleemann, Kilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kolbe, Carl-Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Santarelli, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Castro-Gomez, Sergio UNSPECIFIED orcid.org/0000-0002-1581-474X UNSPECIFIED Tacik, Pawel UNSPECIFIED UNSPECIFIED UNSPECIFIED Latz, Eicke UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Heneka, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-318936
DOI:	10.1111/jnc.15175
Journal or Publication Title:	J. Neurochem.
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1471-4159
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CEREBROSPINAL-FLUID FERRITIN; AMYLOID PRECURSOR PROTEIN; MILD COGNITIVE IMPAIRMENT; OXIDATIVE DAMAGE; CSF NEUROGRANIN; IRON STATUS; INFLAMMATION; BRAIN; PLASMA; TRANSLATION Multiple languages Biochemistry & Molecular Biology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31893