High-intensity interval training reduces neutrophil-to-lymphocyte ratio in persons with multiple sclerosis during inpatient rehabilitation

Joisten, Niklas, Proschinger, Sebastian, Rademacher, Annette, Schenk, Alexander, Bloch, Wilhelm, Warnke, Clemens, Gonzenbach, Roman, Kool, Jan ORCID: 0000-0002-7074-8589, Bansi, Jens and Zimmer, Philipp . High-intensity interval training reduces neutrophil-to-lymphocyte ratio in persons with multiple sclerosis during inpatient rehabilitation. Mult. Scler. J.. LONDON: SAGE PUBLICATIONS LTD. ISSN 1477-0970

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DOI:10.1177/1352458520951382

Abstract

In persons with multiple sclerosis (PwMS), the neutrophil-to-lymphocyte ratio (NLR) is associated with disability status, symptomatology and disease activity. High-intensity interval training (HIIT) improves many symptoms in PwMS and may positively influence disease progression. Here, we present results from a randomized controlled trial during inpatient rehabilitation on immediate (single bout) and training (3-week intervention) effects of HIIT versus moderate continuous training on NLR and related cellular inflammation markers. Only HIIT reduced the NLR over the 3-week intervention period. These training effects might be due to repetitive inflammatory states with compensatory anti-inflammatory counterbalancing after each HIIT session.

Item Type:

Journal Article

Creators:

Creators	Email	ORCID	ORCID Put Code
Joisten, Niklas	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Proschinger, Sebastian	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Rademacher, Annette	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Schenk, Alexander	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Bloch, Wilhelm	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Warnke, Clemens	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Gonzenbach, Roman	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Kool, Jan	UNSPECIFIED	orcid.org/0000-0002-7074-8589	UNSPECIFIED
Bansi, Jens	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Zimmer, Philipp	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED