Universität zu Köln

Narumiya, Kosuke ORCID: 0000-0001-9133-5452, Bollschweiler, Elfriede, Hoelscher, Arnulf H., Yamamoto, Masakazu, Drebber, Uta, Alakus, Hakan, Metzger, Ralf and Warnecke-Eberz, Ute (2020). Different response rates to chemotherapy between Japanese and German esophageal squamous cell carcinoma: patients may be influenced by ERCC1 or ABCB1. Future Oncol., 16 (27). S. 2075 - 2088. LONDON: FUTURE MEDICINE LTD. ISSN 1744-8301

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Abstract

Aim: To find out differences in biomarkers between Japanese and German patients responsible for response after neoadjuvant radio/chemotherapy and survival for esophageal squamous cell carcinoma. Materials & methods: A total of 60 patients from Japan and 127 patients from Germany with esophageal squamous cell carcinoma were analyzed according to three SNPs by real-time PCR. Results: The distribution of the genotypes of ERCC1 rs16115 and ABCB1 C3435T rs1045642 was significantly different between both patients' groups. Japanese patients had significantly less good response to 5-fluorouracil/cisplatin chemotherapy. The influence of the three SNPs on response varied between patients from Japan and Germany. Conclusion: Different expressions of ERCC1 and ABCB1 SNPs of Japanese patients compared with the German patients partially explain the different response.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Narumiya, Kosuke UNSPECIFIED orcid.org/0000-0001-9133-5452 UNSPECIFIED Bollschweiler, Elfriede UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoelscher, Arnulf H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yamamoto, Masakazu UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Alakus, Hakan UNSPECIFIED UNSPECIFIED UNSPECIFIED Metzger, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Warnecke-Eberz, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-320045
DOI:	10.2217/fon-2020-0489
Journal or Publication Title:	Future Oncol.
Volume:	16
Number:	27
Page Range:	S. 2075 - 2088
Date:	2020
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1744-8301
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEOADJUVANT RADIOCHEMOTHERAPY; MULTIMODALITY TREATMENT; GENETIC POLYMORPHISMS; CLINICAL-OUTCOMES; COLORECTAL-CANCER; RNA EXPRESSION; COLON-CANCER; PHASE-II; CHEMORADIATION; IMPACT Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32004