Wolfsgruber, Steffen, Kleineidam, Luca, Guski, Jannis, Polcher, Alexandra, Frommann, Ingo, Roeske, Sandra, Spruth, Eike Jakob, Franke, Christiana, Priller, Josef, Kilimann, Ingo, Teipel, Stefan, Buerger, Katharina, Janowitz, Daniel, Laske, Christoph, Buchmann, Martina, Peters, Oliver, Menne, Felix ORCID: 0000-0003-1574-4443, Fuentes Casan, Manuel, Wiltfang, Jens, Bartels, Claudia, Duezel, Emrah, Metzger, Coraline, Glanz, Wenzel, Thelen, Manuela, Spottke, Annika, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Kofler, Barbara, Fliessbach, Klaus, Schneider, Anja, Heneka, Michael T., Brosseron, Frederic, Meiberth, Dix, Jessen, Frank and Wagner, Michael (2020). Minor neuropsychological deficits in patients with subjective cognitive decline. Neurology, 95 (9). S. E1134 - 10. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1526-632X

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Abstract

Objective To determine the nature and extent of minor neuropsychological deficits in patients with subjective cognitive decline (SCD) and their association with CSF biomarkers of Alzheimer disease (AD). Method We analyzed data from n = 449 cognitively normal participants (n = 209 healthy controls, n = 240 patients with SCD) from an interim data release of the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE). An extensive neuropsychological test battery was applied at baseline for which we established a latent, 5 cognitive domain factor structure comprising learning and memory, executive functions, language abilities, working memory, and visuospatial functions. We compared groups in terms of global and domain-specific performance and correlated performance with different CSF markers of AD pathology. Results We observed worse performance (Cohen d = approximate to 0.25-0.5, adjusted for age, sex differences with analysis of covariance) in global performance, memory, executive functions, and language abilities for the SCD group compared to healthy controls. In addition, worse performance in these domains was moderately (r= approximate to 0.3) associated with lower CSF beta-amyloid(42/40)and CSF beta-amyloid(42)/phosphorylated tau181 in the whole sample and specifically in the SCD subgroup. Conclusions Within the spectrum of clinically unimpaired (i.e., before mild cognitive impairment) cognitive performance, SCD is associated with minor deficits in memory, executive function, and language abilities. The association of these subtle cognitive deficits with AD CSF biomarkers speaks to their validity and potential use for the early detection of underlying preclinical AD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kleineidam, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guski, JannisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polcher, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frommann, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roeske, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spruth, Eike JakobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, ChristianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Priller, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilimann, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teipel, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buerger, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janowitz, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laske, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buchmann, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Menne, FelixUNSPECIFIEDorcid.org/0000-0003-1574-4443UNSPECIFIED
Fuentes Casan, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiltfang, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartels, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duezel, EmrahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metzger, CoralineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glanz, WenzelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thelen, ManuelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Kofler, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fliessbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heneka, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brosseron, FredericUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meiberth, DixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-320207
DOI: 10.1212/WNL.0000000000010142
Journal or Publication Title: Neurology
Volume: 95
Number: 9
Page Range: S. E1134 - 10
Date: 2020
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1526-632X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ALZHEIMERS-DISEASE; MEMORY; IMPAIRMENT; FRAMEWORK; DEMENTIAMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32020

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