Universität zu Köln

Krause, Guenter ORCID: 0000-0003-3905-0921, Hassenrueck, Floyd and Hallek, Michael (2020). Relevant Cytokines in the B Cell Lymphoma Micro-Environment. Cancers, 12 (9). BASEL: MDPI. ISSN 2072-6694

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Abstract

Cytokines are soluble protein factors with importance in intercellular communication and, as such, play pivotal roles in the pathogenesis of B cell malignancies. Evidence from in vitro cultures permitted us to choose example cytokines that bind to different biochemical receptor types. Activated malignant B cells or stromal fibroblasts and macrophages prominently secrete the chemokines CCL3 or CXCL12 and CXCL13, respectively. Apart from helper T cells, various cell types of the B cell lymphoma microenvironment are capable of producing the cytokines IL-4, IL-6, IL-10 and TNF alpha. Owing to its impact on the development of myeloid cells, CSF-1 is among important soluble factors in the B cell lymphoma microenvironment. Inhibitors of B cell receptor-associated kinases often act via the blockade of cytokine production, but also prevent cytokine effects, e.g., chemotaxis. Increments in blood levels in chronic lymphocytic leukemia patients compared to healthy donors and normalization upon treatment with ibrutinib can be explained by producing cell types and modulation of cytokine production observed in vitro.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Krause, Guenter UNSPECIFIED orcid.org/0000-0003-3905-0921 UNSPECIFIED Hassenrueck, Floyd UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-320281
DOI:	10.3390/cancers12092525
Journal or Publication Title:	Cancers
Volume:	12
Number:	9
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC LYMPHOCYTIC-LEUKEMIA; TUMOR-MICROENVIRONMENT; EXPRESSION; MACROPHAGES; INHIBITOR; SURVIVAL; RECEPTOR; KINASE; APOPTOSIS; IBRUTINIB Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32028