Eberhardt, Kirsten Alexandra, Meyer-Schwickerath, Charlotte, Heger, Eva, Knops, Elena, Lehmann, Clara, Rybniker, Jan, Schommers, Philipp ORCID: 0000-0003-3375-6800, Eichenauer, Dennis A., Kurth, Florian, Ramharter, Michael ORCID: 0000-0002-9259-1885, Kaiser, Rolf, Holtick, Udo, Klein, Florian, Jung, Norma and Di Cristanziano, Veronica (2020). RNAemia Corresponds to Disease Severity and Antibody Response in Hospitalized COVID-19 Patients. Viruses-Basel, 12 (9). BASEL: MDPI. ISSN 1999-4915

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a global health emergency. To improve the understanding of the systemic component of SARS-CoV-2, we investigated if viral load dynamics in plasma and respiratory samples are associated with antibody response and severity of coronavirus disease 2019 (COVID-19). SARS-CoV-2 RNA was found in plasma samples from 14 (44%) out of 32 patients. RNAemia was detected in 5 out of 6 fatal cases. Peak IgG values were significantly lower in mild/moderate than in severe (0.6 (interquartile range, IQR, 0.4-3.2) vs. 11.8 (IQR, 9.9-13.0), adjustedp= 0.003) or critical cases (11.29 (IQR, 8.3-12.0), adjustedp= 0.042). IgG titers were significantly associated with virus Ct (Cycle threshold) value in plasma and respiratory specimens ((ss = 0.4, 95% CI (confidence interval, 0.2; 0.5),p< 0.001 and ss = 0.5, 95% CI (0.2; 0.6),p= 0.002). A classification as severe or a critical case was additionally inversely associated with Ct values in plasma in comparison to mild/moderate cases (ss = -3.3, 95% CI (-5.8; 0.8),p= 0.024 and ss = -4.4, 95% CI (-7.2; 1.6),p= 0.007, respectively). Based on the present data, our hypothesis is that the early stage of SARS-CoV-2 infection is characterized by a primary RNAemia, as a potential manifestation of a systemic infection. Additionally, the viral load in plasma seems to be associated with a worse disease outcome.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Eberhardt, Kirsten AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer-Schwickerath, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heger, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knops, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehmann, ClaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rybniker, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schommers, PhilippUNSPECIFIEDorcid.org/0000-0003-3375-6800UNSPECIFIED
Eichenauer, Dennis A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kurth, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramharter, MichaelUNSPECIFIEDorcid.org/0000-0002-9259-1885UNSPECIFIED
Kaiser, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holtick, UdoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klein, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jung, NormaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Di Cristanziano, VeronicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-320420
DOI: 10.3390/v12091045
Journal or Publication Title: Viruses-Basel
Volume: 12
Number: 9
Date: 2020
Publisher: MDPI
Place of Publication: BASEL
ISSN: 1999-4915
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SARS CORONAVIRUS; PROVED VIREMIA; PLASMA; BLOOD; RNA; INFECTIONMultiple languages
VirologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32042

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