Universität zu Köln

Oschmann, Meike and Gawryluk, Jodie R. (2020). A Longitudinal Study of Changes in Resting-State Functional Magnetic Resonance Imaging Functional Connectivity Networks During Healthy Aging. Brain Connect., 10 (7). S. 377 - 385. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 2158-0022

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Abstract

Background:Vast increases in life expectancy over the last century have led to shifts in population demographics and the emergence of a largely aged population, globally. This has led to a need to understand neurobiological changes associated with healthy aging. Studies on age-related changes in functional connectivity networks have largely been cross-sectional and focused on the default mode network (DMN). The current study investigated longitudinal changes in functional connectivity in multiple resting-state networks over 4 years of aging in cognitively normal older adults. Methods:Resting-state functional magnetic resonance imaging scans from older adults (n = 16) who maintained cognitive normal status over 4 years were retrieved at baseline and follow-up from the Alzheimer's Disease Neuroimaging Initiative database. A seed-based approach was executed in Functional MRI of the Brain Software Library (FSL) to examine significant changes in functional connectivity within the DMN, frontoparietal network (FPN), and salience network (SN) within subjects over time. Results:Results indicated significantly (p < 0.05, corrected) reduced functional connectivity in the FPN and SN, but not in the DMN at year 4 compared with baseline in older adults who were cognitively stable. Conclusions:The current study highlights the importance of a longitudinal approach for understanding changes in functional connectivity. The findings also underscore the need to examine multiple networks within the same participants, given that changes were apparent in the FPN and SN but not in the DMN. Future studies should also examine changes in internetwork connectivity as well as shifts in structural connectivity over time.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Oschmann, Meike UNSPECIFIED UNSPECIFIED UNSPECIFIED Gawryluk, Jodie R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-321339
DOI:	10.1089/brain.2019.0724
Journal or Publication Title:	Brain Connect.
Volume:	10
Number:	7
Page Range:	S. 377 - 385
Date:	2020
Publisher:	MARY ANN LIEBERT, INC
Place of Publication:	NEW ROCHELLE
ISSN:	2158-0022
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FRONTOPARIETAL CONTROL; COMPOSITE SCORE; BRAIN NETWORKS; DEFAULT; FMRI; AGE; ROBUST; OPTIMIZATION; REGISTRATION; ACCURATE Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32133