Universität zu Köln

Rempel, Vadim, Grandoch, Andrea, Safi, Ali-Farid, Buller, Johannes, Riekert, Maximilian, Schick, Volker, Nickenig, Hans-Joachim, Zoeller, Joachim and Kreppel, Matthias (2020). The prognostic implications of comorbidity and risk factors for (post) operative complications, days spent in the intensive care unit (ICU), and length of hospitalization in patients with oral squamous cell carcinoma: A prospective study. J. Cranio-MaxilloFac. Surg., 48 (9). S. 868 - 875. EDINBURGH: CHURCHILL LIVINGSTONE. ISSN 1878-4119

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Abstract

Background: This study aimed to investigate the prognostic implications of comorbidity/risk factors in a cohort of patients with OSCC. Methods: The prospective study included patients with biopsy-proven primary OSCC. The impact of potential predictors on (post)operative complications, days spent in the ICU, and length of hospitalization was analyzed using both univariate and multivariate analysis. Results: Using a microvascular free flap (p = 0.009) and tobacco abuse (p = 0.005) had statistically significant impacts on postoperative complications in univariate, but not in multivariate, analysis. The duration of anesthesia (p < 0.001), type of neck dissection (p = 0.014), reconstruction type (p < 0.001), and red blood cell transfusion during operation (p = 0.007) had statistically significant impacts on spending >= 3 days in ICU in univariate analysis, with reconstruction type (p = 0.022) and red blood cell transfusion during operation (p = 0.034) having similar impacts in multivariate analysis. The duration of anesthesia (p < 0.001), pT (p = 0.009), type of neck dissection (p = 0.046), reconstruction type (p < 0.001), and microvascular free flap (p < 0.001) had a statistically significant impacts on length of hospitalization in univariate analysis, with reconstruction type (p < 0.001) also having a significant impact in multivariate analysis. Conclusion: None of the investigated variables showed a significant effect on the prediction of (post) operative complications according to the Clavien-Dindo classification. The type of reconstruction proved to be a valid predictor for the time spent in ICU as well as for the overall length of hospitalization. Red blood cell transfusion during operation further predicted the time spent in ICU after operation. Both variables should be taken into account when performing a comprehensive planning of the patients' hospitalization. (C) 2020 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rempel, Vadim UNSPECIFIED UNSPECIFIED UNSPECIFIED Grandoch, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Safi, Ali-Farid UNSPECIFIED UNSPECIFIED UNSPECIFIED Buller, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Riekert, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schick, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Nickenig, Hans-Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-321693
DOI:	10.1016/j.jcms.2020.07.004
Journal or Publication Title:	J. Cranio-MaxilloFac. Surg.
Volume:	48
Number:	9
Page Range:	S. 868 - 875
Date:	2020
Publisher:	CHURCHILL LIVINGSTONE
Place of Publication:	EDINBURGH
ISSN:	1878-4119
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLAVIEN-DINDO CLASSIFICATION; SURGICAL COMPLICATIONS; MULTIVARIATE-ANALYSIS; WOUND-INFECTION; HEAD; CANCER; FLAP; SURGERY; MANAGEMENT; MORTALITY Multiple languages Dentistry, Oral Surgery & Medicine; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32169