Universität zu Köln

Herkenrath, S. D., Treml, M., Anduleit, N., Richter, K., Pietzke-Calcagnile, A., Schwaibold, M., Schaefer, R., Alshut, R., Grimm, A., Hagmeyer, L. and Randerath, W. J. (2020). Extended evaluation of the efficacy of a proactive forced oscillation technique-based auto-CPAP algorithm. Sleep Breath., 24 (3). S. 825 - 834. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1522-1709

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Abstract

Purpose Previous studies revealed substantially varying therapy efficacy of automatic continuous positive airway pressure (APAP) devices in the treatment of obstructive sleep apnea (OSA). We evaluated the efficacy of a new APAP device using the forced oscillation technique (FOT) to evaluate upper airway obstruction during apneas and flow contour analyses during hypopneas. Methods Forty-six initially diagnosed OSA patients were included and the pressure range was set from 5 to 20 hPa. Therapy efficacy was assessed based on the reduction of apnea-hypopnea index (AHI), improvement of objective sleep quality parameters, and the appropriateness of the device's pressure regulation. Results AHI and arousal index significantly decreased during APAP therapy (median [interquartile range]: AHI 36 [23-55] vs. 2 [1-6]/h, arousal index 30 [22-45] vs. 15 [10-19]/h, bothp < 0.001). The amount of slow wave sleep (SWS) and rapid-eye-movement (REM) sleep significantly increased (SWS 20 [14-29] vs. 29 [19-34]%, REM 16 [11-21] vs. 24 [14-30]%, bothp < 0.01). Most residual respiratory events during therapy were of central etiology and attributable to five patients, who presented with treatment-emergent central sleep apnea. The device's pressure regulation abolished most obstructive respiratory events (n = 6.7 residual obstructive events per patient). Of central respiratory events, 534/646 (83%) did not lead to pressure increases. Conclusion This pilot study provides a proof of concept that the APAP device combining FOT and evaluation of flow contour allows for the suppression of obstructive events without relevant false reactions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herkenrath, S. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Treml, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Anduleit, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Richter, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pietzke-Calcagnile, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwaibold, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Alshut, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimm, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagmeyer, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Randerath, W. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-322147
DOI:	10.1007/s11325-019-01901-8
Journal or Publication Title:	Sleep Breath.
Volume:	24
Number:	3
Page Range:	S. 825 - 834
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1522-1709
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITIVE AIRWAY PRESSURE; OBSTRUCTIVE SLEEP-APNEA; TITRATION; HYPOPNEA; ACCURACY; OUTCOMES; THERAPY; DEVICES Multiple languages Clinical Neurology; Respiratory System Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32214