Stemler, Jannik ORCID: 0000-0001-9152-2469, Hamed, Kamal ORCID: 0000-0003-1896-9736, Salmanton-Garcia, Jon ORCID: 0000-0002-6766-8297, Rezaei-Matehkolaei, Ali, Graefe, Stefanie K., Sal, Ertan, Zarrouk, Marouan, Seidel, Danila, Khedr, Reham Abdelaziz, Ben-Ami, Ronen ORCID: 0000-0003-0628-0798, Ben-Chetrit, Eli, Roth, Yehudah and Cornely, Oliver A. (2020). Mucormycosis in the Middle East and North Africa: Analysis of the FungiScope(R)registry and cases from the literature. Mycoses, 63 (10). S. 1060 - 1069. HOBOKEN: WILEY. ISSN 1439-0507

Full text not available from this repository.

Abstract

Background Regional differences in the underlying causes, manifestations and treatment of mucormycosis have been noted in studies covering Europe, Asia and South America. Objectives To review cases of mucormycosis across the Middle East and North Africa (MENA) region in order to identify epidemiological, treatment and outcome trends in this region. Patients/Methods Cases of proven or probable invasive mucormycosis from the region were identified from the FungiScope(R)database and the medical literature. For each case, information on underlying condition, site of infection, pathogenic species, therapeutic intervention, type of antifungal therapy and outcome were analysed. Results We identified 310 cases of mucormycosis in the MENA region. The number of reported cases increased by decade from 23 before 1990 to 127 in the 2010s. In this region, the most common underlying conditions associated with mucormycosis were diabetes mellitus (49.7%) and conditions associated with immunosuppression (46.5%). The majority of patients received treatment with antifungals (93.5%), with a large proportion treated with both antifungals and surgery (70.6%). Overall mortality rates decreased from 47.8% before 1990 to 32.3% in the 2010s. Conclusions The number of reported cases of mucormycosis in the MENA region has risen over the past few decades, in line with increases in the number of patients with underlying conditions associated with this infection. Although the majority of patients received treatment with antifungal therapies and/or surgery, the associated mortality rate remains high and there is a clear need for more effective prevention and treatment strategies in the MENA region.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Stemler, JannikUNSPECIFIEDorcid.org/0000-0001-9152-2469UNSPECIFIED
Hamed, KamalUNSPECIFIEDorcid.org/0000-0003-1896-9736UNSPECIFIED
Salmanton-Garcia, JonUNSPECIFIEDorcid.org/0000-0002-6766-8297UNSPECIFIED
Rezaei-Matehkolaei, AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graefe, Stefanie K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sal, ErtanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zarrouk, MarouanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seidel, DanilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khedr, Reham AbdelazizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ben-Ami, RonenUNSPECIFIEDorcid.org/0000-0003-0628-0798UNSPECIFIED
Ben-Chetrit, EliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roth, YehudahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-322396
DOI: 10.1111/myc.13123
Journal or Publication Title: Mycoses
Volume: 63
Number: 10
Page Range: S. 1060 - 1069
Date: 2020
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1439-0507
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ZYGOMYCOSIS; FRANCEMultiple languages
Dermatology; MycologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32239

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item