Universität zu Köln

Messa, Guy A. M., Piasecki, Mathew ORCID: 0000-0002-7804-4631, Rittweger, Joern, McPhee, Jamie S., Koltai, Erika, Radak, Zsolt, Simunic, Bostjan, Heinonen, Ari ORCID: 0000-0002-3681-9953, Suominen, Harri, Korhonen, Marko T. ORCID: 0000-0003-2550-0784 and Degens, Hans (2020). Absence of an aging-related increase in fiber type grouping in athletes and non-athletes. Scand. J. Med. Sci. Sports, 30 (11). S. 2057 - 2070. HOBOKEN: WILEY. ISSN 1600-0838

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Abstract

The aging-related loss of muscle mass is thought to be partly attributable to motor neuron loss and motor unit remodeling that result in fiber type grouping. We examined fiber type grouping in 19- to 85-year-old athletes and non-athletes and evaluated to which extent any observed grouping is explained by the fiber type composition of the muscle. Since regular physical activity may stimulate reinnervation, we hypothesized that fiber groups are larger in master athletes than in age-matched non-athletes. Fiber type grouping was assessed inm. vastus lateralisbiopsies from 22 young (19-27 years) and 35 healthy older (66-82 years) non-athletes, and 14 young (20-29 years), 51 middle-aged (38-65 years), and 31 older (66-85 years) athletes. An enclosed fiber was any muscle fiber of a particular type surrounded by fibers of the same type only. A fiber type group was defined as a group of fibers with at least one enclosed fiber. Only type II fiber cross-sectional area (FCSA) showed an age-related decline that was greater in athletes (P < .001) than in non-athletes (P = .012). There was no significant age-related effect on fiber group size or fiber group number in athletes or non-athletes, and the observed grouping was similar to that expected from the fiber type composition. At face value, these observations do 1) neither show evidence for an age-related loss and remodeling of motor units nor 2) improved reinnervation with regular physical activity, but 3) histological examination may not reveal the full extent of aging-related motor unit remodeling.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Messa, Guy A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Piasecki, Mathew UNSPECIFIED orcid.org/0000-0002-7804-4631 UNSPECIFIED Rittweger, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED McPhee, Jamie S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koltai, Erika UNSPECIFIED UNSPECIFIED UNSPECIFIED Radak, Zsolt UNSPECIFIED UNSPECIFIED UNSPECIFIED Simunic, Bostjan UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinonen, Ari UNSPECIFIED orcid.org/0000-0002-3681-9953 UNSPECIFIED Suominen, Harri UNSPECIFIED UNSPECIFIED UNSPECIFIED Korhonen, Marko T. UNSPECIFIED orcid.org/0000-0003-2550-0784 UNSPECIFIED Degens, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-322461
DOI:	10.1111/sms.13778
Journal or Publication Title:	Scand. J. Med. Sci. Sports
Volume:	30
Number:	11
Page Range:	S. 2057 - 2070
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0838
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN SKELETAL-MUSCLES; MOTOR UNIT NUMBER; WHOLE VASTUS LATERALIS; PHYSICAL-ACTIVITY; CROSS-SECTIONS; OLDER MEN; AGE; YOUNG; SIZE; CONTRACTILE Multiple languages Sport Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32246