Universität zu Köln

Pennig, Lenhard, Wagner, Anton, Weiss, Kilian, Lennartz, Simon, Huntgeburth, Michael, Hickethier, Tilman, Maintz, David, Naehle, Claas Philip, Bunck, Alexander Christian and Doerner, Jonas . Comparison of a novel Compressed SENSE accelerated 3D modified relaxation-enhanced angiography without contrast and triggering with CE-MRA in imaging of the thoracic aorta. Int. J. Cardiovasc. Imaging. DORDRECHT: SPRINGER. ISSN 1573-0743

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Abstract

To compare a novel Compressed SENSE accelerated ECG- and respiratory-triggered flow-independent 3D isotropic Relaxation-Enhanced Angiography without Contrast and Triggering (modified REACT) with standard non-ECG-triggered 3D contrast-enhanced magnetic resonance angiography (CE-MRA) for imaging of the thoracic aorta in patients with connective tissue diseases (CTD) or other aortic diseases using manual and semiautomatic measurement approaches. This retrospective, single-center analysis of 30 patients (June-December 2018) was conducted by two radiologists, who independently measured aortic diameters on modified REACT and CE-MRA using manual (Multiplanar-Reconstruction) and semiautomatic (Advanced Vessel Analysis) measurement tools on seven levels (inner edge): Aortic annulus and sinus, sinotubular junction, mid- and high-ascending aorta, aortic isthmus, and descending aorta. Bland-Altman analysis was conducted to evaluate differences between the mean values of aortic width and ICCs were calculated to assess interobserver agreement. For each level, image quality was evaluated on a four-point scale in consensus with Wilcoxon matched-pair test used to evaluate for differences between both MRA techniques. Additionally, evaluation time for each measurement technique was noted, which was compared applying one-way ANOVA. When comparing both imaging and measurement methods, CE-MRA (mean difference 0.24 +/- 0.27 mm) and the AVA-tool (- 0.21 +/- 0.15 mm) yielded higher differences compared to modified REACT (- 0.11 +/- 0.11 mm) and the MPR-tool (0.07 +/- 0.21 mm) for all measurement levels combined without yielding clinical significance. There was an excellent interobserver agreement between modified REACT and CE-MRA using both tools of measurement (ICC > 0.9). Modified REACT (average acquisition time 06:34 +/- 01:36 min) provided better image quality from aortic annulus to mid-ascending aorta (p < 0.05), whereas at distal measurement levels, no significant differences were noted. Regarding time requirement, no statistical significance was found between both measurement techniques (p = 0.08). As a novel non-CE-MRA technique, modified REACT allows for fast imaging of the thoracic aorta with higher image quality in the proximal aorta than CE-MRA enabling a reliable measurement of vessel dimensions without the need for contrast agent. Thus, it represents a clinically suitable alternative for patients requiring repetitive imaging. Manual and semiautomatic measurement approaches provided comparable results without significant difference in time need.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pennig, Lenhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Kilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Lennartz, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Huntgeburth, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Hickethier, Tilman UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Naehle, Claas Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED Bunck, Alexander Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Doerner, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-322558
DOI:	10.1007/s10554-020-01979-2
Journal or Publication Title:	Int. J. Cardiovasc. Imaging
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	1573-0743
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MAGNETIC-RESONANCE ANGIOGRAPHY; DIAMETER MEASUREMENTS; MARFAN-SYNDROME; GADOLINIUM; DISEASE; HEART; SSFP; TOMOGRAPHY; GUIDELINES; MANAGEMENT Multiple languages Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32255