Universität zu Köln

Craig, Austin, Kolks, Niklas, Urusova, Elizaveta A., Zischler, Johannes, Brugger, Melanie, Endepols, Heike, Neumaier, Bernd ORCID: 0000-0001-5425-3116 and Zlatopolskiy, Boris D. (2020). Preparation of labeled aromatic amino acidsvialate-stage(18)F-fluorination of chiral nickel and copper complexes. Chem. Commun., 56 (66). S. 9505 - 9509. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1364-548X

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Abstract

A general protocol for the preparation of(18)F-labeled AAAs and alpha-methyl-AAAs applying alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral complexes using Ni/Cu-BPX templates as double protecting groups is reported. The chiral auxiliaries are easily accessible from commercially available starting materials in a few synthetic steps. The versatility of the method was demonstrated by the high-yielding preparation of a series of [F-18]F-AAAs and the successful implementation of the protocol into automated radiosynthesis modules.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Craig, Austin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kolks, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Urusova, Elizaveta A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zischler, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Brugger, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Endepols, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED orcid.org/0000-0001-5425-3116 UNSPECIFIED Zlatopolskiy, Boris D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-322723
DOI:	10.1039/d0cc02223c
Journal or Publication Title:	Chem. Commun.
Volume:	56
Number:	66
Page Range:	S. 9505 - 9509
Date:	2020
Publisher:	ROYAL SOC CHEMISTRY
Place of Publication:	CAMBRIDGE
ISSN:	1364-548X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NO-CARRIER; MEDIATED RADIOFLUORINATION; F-18-FDG PET; ESTERS; TUMOR Multiple languages Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32272