Bandini, Marco, Spiess, Philippe E., Pederzoli, Filippo ORCID: 0000-0003-3873-7465, Marandino, Laura ORCID: 0000-0001-7120-2505, Brouwer, Oscar R., Albersen, Maarten, Roussel, Eduard ORCID: 0000-0002-7835-5536, de Vries, Hielke M., Chipollini, Juan ORCID: 0000-0003-2603-0382, Zhu, Yao, Ye, Ding-Wei, Ornellas, Antonio A., Catanzaro, Mario, Hakenberg, Oliver W., Heidenreich, Axel, Haidl, Friederike, Watkin, Nick, Ager, Michael, Ahmed, Mohamed E., Karnes, Jeffrey R., Briganti, Alberto, Salvioni, Roberto, Montorsi, Francesco, Azizi, Mounsif and Necchi, Andrea (2020). A risk calculator predicting recurrence in lymph node metastatic penile cancer. BJU Int., 126 (5). S. 577 - 586. HOBOKEN: WILEY. ISSN 1464-410X

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Abstract

Objectives To develop and externally validate a risk calculator for prediction of any cancer recurrence in patients with penile squamous cell carcinoma (pSCC) and inguinal lymph node metastases (ILNM), as to date no validated prognostic tool is available for patients with pSCC and ILNM. Patients and Methods The development cohort included 234 patients from seven referral centres. The external validation cohort included 273 patients from two additional referral centres. Cox regression identified predictors of any recurrence, which were used to develop a risk calculator. The risk-calculator grouped the development and the validation cohorts according to the individual risk of any recurrence at 24 months (24m-R). Adjuvant treatment effects were tested on overall survival (OS) according to the derived tertiles, within the development and validation cohorts. Results Positive surgical margins, pN(3), and ILNM ratio were associated with higher recurrence rate. The 2-year OS rates were lower for patients with high (>37%) and intermediate (19-37%) compared to low (<19%) 24m-R risk of recurrence, for both the development (43% and 58% vs 83%,P < 0.001) and validation cohort (44% and 50% vs 85%,P < 0.001). Results were confirmed in the subgroup of patients who did not receive adjuvant treatment (P < 0.001), but not in patients who did receive adjuvant treatments in both the development and validation cohorts (P > 0.1). Conclusion Adjuvant treatment planning is crucial in patients with pSCC with ILNM, where only weak evidence is available. The current tool proved to successfully stratify patients according to their individual risk, potentially allowing better tailoring of adjuvant treatments.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bandini, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spiess, Philippe E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pederzoli, FilippoUNSPECIFIEDorcid.org/0000-0003-3873-7465UNSPECIFIED
Marandino, LauraUNSPECIFIEDorcid.org/0000-0001-7120-2505UNSPECIFIED
Brouwer, Oscar R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albersen, MaartenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roussel, EduardUNSPECIFIEDorcid.org/0000-0002-7835-5536UNSPECIFIED
de Vries, Hielke M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chipollini, JuanUNSPECIFIEDorcid.org/0000-0003-2603-0382UNSPECIFIED
Zhu, YaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ye, Ding-WeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ornellas, Antonio A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Catanzaro, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hakenberg, Oliver W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heidenreich, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haidl, FriederikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Watkin, NickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ager, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahmed, Mohamed E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karnes, Jeffrey R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Briganti, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salvioni, RobertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montorsi, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azizi, MounsifUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Necchi, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-323740
DOI: 10.1111/bju.15177
Journal or Publication Title: BJU Int.
Volume: 126
Number: 5
Page Range: S. 577 - 586
Date: 2020
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1464-410X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SQUAMOUS-CELL CARCINOMA; UNITED-STATES; SURVIVAL; CHEMOTHERAPYMultiple languages
Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32374

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