Maurus, Isabel, Hasan, Alkomiet, Schmitt, Andrea, Roeh, Astrid, Keeser, Daniel ORCID: 0000-0002-0244-1024, Malchow, Berend, Schneider-Axmann, Thomas, Hellmich, Martin, Schmied, Sabine, Lembeck, Moritz, Keller-Varady, Katriona, Papazova, Irina, Hirjak, Dusan, Topor, Cristina E., Walter, Henrik, Mohnke, Sebastian, Vogel, Bob O., Woelwer, Wolfgang, Schneider, Frank, Henkel, Karsten, Meyer-Lindenberg, Andreas and Falkai, Peter ORCID: 0000-0003-2873-8667 . Aerobic endurance training to improve cognition and enhance recovery in schizophrenia: design and methodology of a multicenter randomized controlled trial. Eur. Arch. Psych. Clin. Neurosci.. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-8491

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Abstract

Even today, patients with schizophrenia often have an unfavorable outcome. Negative symptoms and cognitive deficits are common features in many patients and prevent recovery. In recent years, aerobic endurance training has emerged as a therapeutic approach with positive effects on several domains of patients' health. However, appropriately sized, multicenter randomized controlled trials that would allow better generalization of results are lacking. The exercise study presented here is a multicenter, rater-blind, two-armed, parallel-group randomized clinical trial in patients with clinically stable schizophrenia being conducted at five German tertiary hospitals. The intervention group performs aerobic endurance training on bicycle ergometers three times per week for 40-50 min/session (depending on the intervention week) for a total of 26 weeks, and the control group performs balance and tone training for the same amount of time. Participants are subsequently followed up for 26 weeks. The primary endpoint isall-cause discontinuation; secondary endpoints include psychopathology, cognition, daily functioning, cardiovascular risk factors, and explorative biological measures regarding the underlying mechanisms of exercise. A total of 180 patients will be randomized. With currently 162 randomized participants, our study is the largest trial to date to investigate endurance training in patients with schizophrenia. We hypothesize that aerobic endurance training has beneficial effects on patients' mental and physical health, leading to lower treatment discontinuation rates and improving disease outcomes. The study results will provide a basis for recommending exercise interventions as an add-on therapy in patients with schizophrenia.The study is registered in the International Clinical Trials Database (ClinicalTrials.gov identifier [NCT number]: NCT03466112) and in the German Clinical Trials Register (DRKS-ID: DRKS00009804).

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Maurus, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasan, AlkomietUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitt, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roeh, AstridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keeser, DanielUNSPECIFIEDorcid.org/0000-0002-0244-1024UNSPECIFIED
Malchow, BerendUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider-Axmann, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellmich, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmied, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lembeck, MoritzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keller-Varady, KatrionaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papazova, IrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hirjak, DusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Topor, Cristina E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walter, HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mohnke, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vogel, Bob O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woelwer, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henkel, KarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer-Lindenberg, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falkai, PeterUNSPECIFIEDorcid.org/0000-0003-2873-8667UNSPECIFIED
URN: urn:nbn:de:hbz:38-324045
DOI: 10.1007/s00406-020-01175-2
Journal or Publication Title: Eur. Arch. Psych. Clin. Neurosci.
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1433-8491
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MAJOR DEPRESSIVE DISORDER; PHYSICAL-ACTIVITY; 1ST-EPISODE SCHIZOPHRENIA; NEGATIVE SYMPTOMS; BIPOLAR DISORDER; ASSESSMENT SCALE; LIFE EXPECTANCY; DSM-IV; METAANALYSIS; EXERCISEMultiple languages
Clinical Neurology; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32404

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