Roberts, S. E., Thorne, K., Thapar, N., Broekaert, I., Benninga, M. A., Dolinsek, J., Mas, E., Miele, E., Orel, R., Pienar, C., Ribes-Koninckx, C., Thomson, M., Tzivinikos, C., Morrison-Rees, S., John, A. and Williams, J. G. (2020). A Systematic Review and Meta-analysis of Paediatric Inflammatory Bowel Disease Incidence and Prevalence Across Europe. J. Crohns Colitis, 14 (8). S. 1119 - 1149. OXFORD: OXFORD UNIV PRESS. ISSN 1876-4479

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Abstract

Background and Aims: Inflammatory bowel disease [IBD] is often one of the most devastating and debilitating chronic gastrointestinal disorders in children and adolescents. The main objectives here were to systematically review the incidence and prevalence of paediatric IBD across all 51 European states. Methods: We undertook a systematic review and meta-analysis based on PubMed, CINAHL, the Cochrane Library, searches of reference lists, grey literature and websites, covering the period from 1970 to 2018. Results: Incidence rates for both paediatric Crohn's disease [CD] and ulcerative colitis [UC] were higher in northern Europe than in other European regions. There have been large increases in the incidence of both paediatric CD and UC over the last 50 years, which appear widespread across Europe. The largest increases for CD have been reported from Sweden, Wales, England, the Czech Republic, Denmark and Hungary, and for UC from the Czech Republic, Ireland, Sweden and Hungary. Incidence rates for paediatric CD have increased up to 9 or 10 per 100 000 population in parts of Europe, including Scandinavia, while rates for paediatric UC are often slightly lower than for CD. Prevalence reported for CD ranged from 8.2 per 100 000 to approximately 60 and, for UC, from 8.3 to approximately 30. Conclusions: The incidence of paediatric IBD continues to increase throughout Europe. There is stronger evidence of a north-south than an east-west gradient in incidence across Europe. Further prospective studies are needed, preferably multinational and based on IBD registries, using standardized definitions, methodology and timescales.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Roberts, S. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thorne, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thapar, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broekaert, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benninga, M. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dolinsek, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mas, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miele, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orel, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pienar, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ribes-Koninckx, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomson, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tzivinikos, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morrison-Rees, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
John, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, J. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-324183
DOI: 10.1093/ecco-jcc/jjaa037
Journal or Publication Title: J. Crohns Colitis
Volume: 14
Number: 8
Page Range: S. 1119 - 1149
Date: 2020
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1876-4479
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ONSET CROHNS-DISEASE; POPULATION-BASED INCEPTION; DRUG-TREATMENT PRACTICES; ULCERATIVE-COLITIS; INCREASING INCIDENCE; SOUTHEASTERN NORWAY; RISING INCIDENCE; WESTERN HUNGARY; FOLLOW-UP; EPIDEMIOLOGIC ASPECTSMultiple languages
Gastroenterology & HepatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32418

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