Universität zu Köln

Koerner, Robert W., Majjouti, Mohamed, Alcazar, Miguel A. Alejandre and Mahabir, Esther (2020). Of Mice and Men: The Coronavirus MHV and Mouse Models as a Translational Approach to Understand SARS-CoV-2. Viruses-Basel, 12 (8). BASEL: MDPI. ISSN 1999-4915

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Abstract

The fatal acute respiratory coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since COVID-19 was declared a pandemic by the World Health Organization in March 2020, infection and mortality rates have been rising steadily worldwide. The lack of a vaccine, as well as preventive and therapeutic strategies, emphasize the need to develop new strategies to mitigate SARS-CoV-2 transmission and pathogenesis. Since mouse hepatitis virus (MHV), severe acute respiratory syndrome coronavirus (SARS-CoV), and SARS-CoV-2 share a common genus, lessons learnt from MHV and SARS-CoV could offer mechanistic insights into SARS-CoV-2. This review provides a comprehensive review of MHV in mice and SARS-CoV-2 in humans, thereby highlighting further translational avenues in the development of innovative strategies in controlling the detrimental course of SARS-CoV-2. Specifically, we have focused on various aspects, including host species, organotropism, transmission, clinical disease, pathogenesis, control and therapy, MHV as a model for SARS-CoV and SARS-CoV-2 as well as mouse models for infection with SARS-CoV and SARS-CoV-2. While MHV in mice and SARS-CoV-2 in humans share various similarities, there are also differences that need to be addressed when studying murine models. Translational approaches, such as humanized mouse models are pivotal in studying the clinical course and pathology observed in COVID-19 patients. Lessons from prior murine studies on coronavirus, coupled with novel murine models could offer new promising avenues for treatment of COVID-19.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koerner, Robert W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Majjouti, Mohamed UNSPECIFIED UNSPECIFIED UNSPECIFIED Alcazar, Miguel A. Alejandre UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahabir, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-324251
DOI:	10.3390/v12080880
Journal or Publication Title:	Viruses-Basel
Volume:	12
Number:	8
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1999-4915
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE RESPIRATORY SYNDROME; HEPATITIS-VIRUS INFECTION; ANGIOTENSIN-CONVERTING ENZYME; SARS-COV; MURINE CORONAVIRUS; BALB/C MICE; INTRANASAL INOCULATION; MOLECULAR DETERMINANTS; FUNCTIONAL RECEPTOR; CHALLENGE IMMUNITY Multiple languages Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32425