Universität zu Köln

Strubl, Sebastian, Torres, Jacob A., Spindt, Alison K., Pellegrini, Hannah, Liebau, Max C. and Weimbs, Thomas ORCID: 0000-0001-9423-5561 (2020). STAT signaling in polycystic kidney disease. Cell. Signal., 72. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-3913

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Abstract

The most common form of polycystic kidney disease (PKD) in humans is caused by mutations in the PKD1 gene coding for polycystin1 (PC1). Among the many identified or proposed functions of PC1 is its ability to regulate the activity of transcription factors of the STAT family. Most STAT proteins that have been investigated were found to be aberrantly activated in kidneys in PKD, and some have been shown to be drivers of disease progression. In this review, we focus on the role of signal transducer and activator of transcription (STAT) signaling pathways in various renal cell types in healthy kidneys as compared to polycystic kidneys, on the mechanisms of STAT regulation by PC1 and other factors, and on the possibility to target STAT signaling for PKD therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Strubl, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Torres, Jacob A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spindt, Alison K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pellegrini, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Liebau, Max C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weimbs, Thomas UNSPECIFIED orcid.org/0000-0001-9423-5561 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-325413
DOI:	10.1016/j.cellsig.2020.109639
Journal or Publication Title:	Cell. Signal.
Volume:	72
Date:	2020
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-3913
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RENAL CYST GROWTH; INTERSTITIAL FIBROBLAST ACTIVATION; TARGETED DISRUPTION; CELL-PROLIFERATION; IN-VIVO; NUCLEAR TRANSLOCATION; TRANSCRIPTION FACTORS; NEGATIVE REGULATOR; RECEPTOR-ACTIVITY; LUPUS NEPHRITIS Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32541