Universität zu Köln

Manuel, Jorge ORCID: 0000-0003-1983-1448, Faerber, Natalia, Gerlach, Darius A., Heusser, Karsten ORCID: 0000-0002-2571-5585, Jordan, Jens, Tanlet, Jens and Beissner, Florian (2020). Deciphering the neural signature of human cardiovascular regulation. eLife, 9. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

Cardiovascular regulation is integral to life. Animal studies have identified both neural and endocrine pathways, by which the central nervous system adjusts cardiac output and peripheral vascular resistance to changing physiological demands. The outflow of these pathways is coordinated by various central nervous regions based on afferent information from baroreceptors, chemoreceptors, nociceptors, and circulating hormones, and is modulated by physiologic and behavioural state. In humans, however, knowledge on central cardiovascular regulation below the cortical level is scarce. Here, we show using functional MRI (fMRI) that at least three hypothalamic subsystems are involved in cardiovascular regulation in humans. The rhythmic behaviour of these systems corresponds to high and low frequency oscillations typically seen in blood pressure and heart rate variability.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Manuel, Jorge UNSPECIFIED orcid.org/0000-0003-1983-1448 UNSPECIFIED Faerber, Natalia UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerlach, Darius A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heusser, Karsten UNSPECIFIED orcid.org/0000-0002-2571-5585 UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Tanlet, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Beissner, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-325593
DOI:	10.7554/eLife.55316
Journal or Publication Title:	eLife
Volume:	9
Date:	2020
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FUNCTIONAL-ORGANIZATION; NORADRENERGIC PATHWAYS; BLOOD-PRESSURE; BRAIN; NUCLEUS; HYPOTHALAMUS; REGISTRATION; VASOPRESSIN; PROJECTIONS; INTEGRATION Multiple languages Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32559