Universität zu Köln

Danial, John S. H., Murad, Fabronia, Saez, Ana-J Garcia, Moawad, Magdy R., Urrico, Giovanni S., Vancheri, Federico ORCID: 0000-0002-5268-063X and Henein, Michael Y. (2020). Computed Histological Quantification of Atherosclerotic Plaque Microcalcifications. Angiology, 71 (10). S. 916 - 920. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1940-1574

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Abstract

Inflammation has a central role in atherosclerotic plaque formation and rupture. Intense macrophage inflammatory activity results in microcalcifications which are strongly associated with plaque vulnerability. Microcalcifications with specific critical size between 5 and 65 mu, located in the fibrous cap producing local mechanical stress on the plaque surface and may directly contribute to plaque rupture. Hence, accurate assessment of microcalcifications size and dimension has significant clinical importance. Current invasive and noninvasive plaque imaging has limited spatial resolution which limits accurate definition of microcalcifications in the atherosclerotic plaques. We describe a new imaging technique with high spatial resolution, based on confocal microscopic analysis, using a dedicated software which allows automatic characterization of microcalcifications and quantitative assessment of their extent and localization.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Danial, John S. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Murad, Fabronia UNSPECIFIED UNSPECIFIED UNSPECIFIED Saez, Ana-J Garcia UNSPECIFIED UNSPECIFIED UNSPECIFIED Moawad, Magdy R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Urrico, Giovanni S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vancheri, Federico UNSPECIFIED orcid.org/0000-0002-5268-063X UNSPECIFIED Henein, Michael Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-326864
DOI:	10.1177/0003319720939466
Journal or Publication Title:	Angiology
Volume:	71
Number:	10
Page Range:	S. 916 - 920
Date:	2020
Publisher:	SAGE PUBLICATIONS INC
Place of Publication:	THOUSAND OAKS
ISSN:	1940-1574
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VASCULAR CALCIFICATION; INFLAMMATION; MECHANISMS; RUPTURE Multiple languages Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32686