Universität zu Köln

Wagner, Steffen, Prigge, Elena-Sophie, Wuerdemann, Nora, Reder, Henrike, Bushnak, Ayman, Sharma, Shachi Jenny, Obermueller, Theresa, Doeberitz, Magnus von Knebel, Dreyer, Thomas, Gattenloehner, Stefan, Wolf, Gregor, Pons-Kuehnemann, Joern, Wittekindt, Claus and Klussmann, Jens Peter (2020). Evaluation of p16(INK4a)expression as a single marker to select patients with HPV-driven oropharyngeal cancers for treatment de-escalation. Br. J. Cancer, 123 (7). S. 1114 - 1123. LONDON: SPRINGERNATURE. ISSN 1532-1827

Full text not available from this repository.

Abstract

Background A remarkably better prognosis is associated with oropharyngeal squamous cell carcinomas (OPSCC) driven by human papillomaviruses (HPV) compared with HPV-negative OPSCC. Consequently, de-escalation of standard treatment has been suggested. Due to modest specificity rates, debates are ongoing, whether p16(INK4a), a surrogate marker for HPV-driven OPSCC, is sufficient to correctly identify those tumours and avoid substantial HPV misattribution and thus undertreatment of patients by de-escalation. Robust data estimating the proportion of potentially undertreated patients are missing. Methods We assessed a large-scale cohort of consecutively included OPSCC diagnosed between 2000 and 2017 for HPV-DNA, HPV genotypes, p16(INK4a)expression and multiple tumour- and patient-related risk factors, and investigated their impact on patients' survival in comprehensive uni- and multivariate analyses. Results Aetiological relevance of HPV (p16(INK4a)- and high-risk HPV-DNA-positivity) was detected in 27.1% (n = 192) of OPSCC, with HPV(16)being the most abundant HPV type (94.6%). In 5.5% patients (n = 39), p16(INK4a)overexpression but no HPV-DNA was detected. Principal component and survival analyses revealed that 60.6% of these p16(INK4a)-positive OPSCC lacking HPV-DNA did not resemble HPV16-driven but HPV-negative OPSCC regarding risk-factor profile and overall survival. Notably, this group represented 10.6% of all p16(INK4a)-overexpressing OPSCC. Conclusions p16(INK4a)as a single marker appears insufficient to indicate OPSCC patients suitable for treatment de-escalation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wagner, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Prigge, Elena-Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Wuerdemann, Nora UNSPECIFIED UNSPECIFIED UNSPECIFIED Reder, Henrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Bushnak, Ayman UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharma, Shachi Jenny UNSPECIFIED UNSPECIFIED UNSPECIFIED Obermueller, Theresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Doeberitz, Magnus von Knebel UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreyer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Gattenloehner, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Pons-Kuehnemann, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittekindt, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Klussmann, Jens Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-326936
DOI:	10.1038/s41416-020-0964-x
Journal or Publication Title:	Br. J. Cancer
Volume:	123
Number:	7
Page Range:	S. 1114 - 1123
Date:	2020
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	1532-1827
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMAS; HUMAN-PAPILLOMAVIRUS; CRITICAL-ISSUES; SURVIVAL Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32693