Universität zu Köln

Theruvath, Ashok J., Siedek, Florian, Muehe, Anne M., Garcia-Diaz, Jordi ORCID: 0000-0001-9325-8403, Kirchner, Julian, Martin, Ole, Link, Michael P., Spunt, Sheri ORCID: 0000-0002-1669-2676, Pribnow, Allison, Rosenberg, Jarrett, Herrmann, Ken, Gatidis, Sergios ORCID: 0000-0002-6928-4967, Schafer, Jurgen F., Moseley, Michael, Umutlu, Lale and Daldrup-Link, Heike E. (2020). Therapy Response Assessment of Pediatric Tumors with Whole-Body Diffusion-weighted MRI and FDG PET/MRI. Radiology, 296 (1). S. 143 - 152. OAK BROOK: RADIOLOGICAL SOC NORTH AMERICA. ISSN 0033-8419

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Abstract

Background: Whole-body diffusion-weighted (DW) MRI can help detect cancer with high sensitivity. However, the assessment of therapy response often requires information about tumor metabolism, which is measured with fluorine 18 fluorodeoxyglucose (FDG) PET. Purpose: To compare tumor therapy response with whole-body DW MRI and FDG PET/MRI in children and young adults. Materials and Methods: In this prospective, nonrandomized multicenter study, 56 children and young adults (31 male and 25 female participants; mean age, 15 years +/- 4 [standard deviation]; age range, 6-22 years) with lymphoma or sarcoma underwent 112 simultaneous whole-body DW MRI and FDG PET/MRI between June 2015 and December 2018 before and after induction chemotherapy(ClinicalTrials.gov identifier: NCT01542879). The authors measured minimum tumor apparent diffusion coefficients (ADCs) and maximum standardized uptake value (SUV) of up to six target lesions and assessed therapy response after induction chemotherapy according to the Lugano classification or PET Response Criteria in Solid Tumors. The authors evaluated agreements between whole-body DW MRI- and FDG PET/MRI-based response classifications with Krippendorff alpha statistics. Differences in minimum ADC and maximum SUV between responders and nonresponders and comparison of timing for discordant and concordant response assessments after induction chemotherapy were evaluated with the Wilcoxon test. Results: Good agreement existed between treatment response assessments after induction chemotherapy with whole-body DW MRI and FDG PET/MRI (alpha = 0.88). Clinical response prediction according to maximum SUV (area under the receiver operating characteristic curve = 100%; 95% confidence interval [CI]: 99%, 100%) and minimum ADC (area under the receiver operating characteristic curve = 98%; 95% CI: 94%, 100%) were similar (P =.37). Sensitivity and specificity were 96% (54 of 56 participants;95% CI: 86%, 99%) and 100% (56 of 56 participants; 95% CI: 54%, 100%), respectively, for DW MRI and 100% (56 of 56 participants; 95% CI: 93%, 100%) and 100% (56 of 56 participants; 95% CI: 54%, 100%) for FDG PET/MRI. In eight of 56 patients who underwent imaging after induction chemotherapy in the early posttreatment phase, chemotherapy-induced changes in tumor metabolism preceded changes in proton diffusion (P =.002). Conclusion: Whole-body diffusion-weighted MRI showed significant agreement with fluorine 18 fluorodeoxyglucose PET/MRI for treatment response assessment in children and young adults. (C) RSNA, 2020

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Theruvath, Ashok J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Siedek, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Muehe, Anne M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia-Diaz, Jordi UNSPECIFIED orcid.org/0000-0001-9325-8403 UNSPECIFIED Kirchner, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin, Ole UNSPECIFIED UNSPECIFIED UNSPECIFIED Link, Michael P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spunt, Sheri UNSPECIFIED orcid.org/0000-0002-1669-2676 UNSPECIFIED Pribnow, Allison UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenberg, Jarrett UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrmann, Ken UNSPECIFIED UNSPECIFIED UNSPECIFIED Gatidis, Sergios UNSPECIFIED orcid.org/0000-0002-6928-4967 UNSPECIFIED Schafer, Jurgen F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moseley, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Umutlu, Lale UNSPECIFIED UNSPECIFIED UNSPECIFIED Daldrup-Link, Heike E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-328445
DOI:	10.1148/radiol.2020192508
Journal or Publication Title:	Radiology
Volume:	296
Number:	1
Page Range:	S. 143 - 152
Date:	2020
Publisher:	RADIOLOGICAL SOC NORTH AMERICA
Place of Publication:	OAK BROOK
ISSN:	0033-8419
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; NEOADJUVANT CHEMOTHERAPY; F-18-FDG PET/CT; LYMPHOMA; GRADE; PREDICTION; CHILDHOOD; CHILDREN; SARCOMAS; CANCER Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32844