Universität zu Köln

Neu, Axel, Hornig, Soenke, Sasani, Ali, Isbrandt, Dirk, Gerloff, Christian, Tsikas, Dimitris, Schwedhelm, Edzard and Choe, Chi-un (2020). Creatine, guanidinoacetate and homoarginine in statin-induced myopathy. Amino Acids, 52 (6-7). S. 1067 - 1070. WIEN: SPRINGER WIEN. ISSN 1438-2199

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Abstract

Our study evaluated the effect of creatine and homoarginine in AGAT- and GAMT-deficient mice after simvastatin exposure. Balestrino and Adriano suggest that guanidinoacetate might explain the difference between AGAT- and GAMT-deficient mice in simvastatin-induced myopathy. We agree with Balestrino and Adriano that our data shows that (1) creatine possesses a protective potential to ameliorate statin-induced myopathy in humans and mice and (2) homoarginine did not reveal a beneficial effect in statin-induced myopathy. Third, we agree that guanidinoacetate can be phosphorylated and partially compensate for phosphocreatine. In our study, simvastatin-induced damage showed a trend to be less pronounced in GAMT-deficient mice compared with wildtype mice. Therefore, (phospo) guanidinoacetate cannot completely explain the milder phenotype of GAMT-deficient mice, but we agree that it might contribute to ameliorate statin-induced myopathy in GAMT-deficient mice compared with AGAT-deficient mice. Finally, we agree with Balestino and Adriano that AGAT metabolites should further be evaluated as potential treatments in statin-induced myopathy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Neu, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Hornig, Soenke UNSPECIFIED UNSPECIFIED UNSPECIFIED Sasani, Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED Isbrandt, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerloff, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Tsikas, Dimitris UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwedhelm, Edzard UNSPECIFIED UNSPECIFIED UNSPECIFIED Choe, Chi-un UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-329030
DOI:	10.1007/s00726-020-02865-w
Journal or Publication Title:	Amino Acids
Volume:	52
Number:	6-7
Page Range:	S. 1067 - 1070
Date:	2020
Publisher:	SPRINGER WIEN
Place of Publication:	WIEN
ISSN:	1438-2199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MUSCLE; DEFICIENCY; MICE Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32903