Lucas, Carolin Weiss, Nettekoven, Charlotte ORCID: 0000-0002-8944-4681, Neuschmelting, Volker, Oros-Peusquens, Ana-Maria, Stoffels, Gabriele, Viswanathan, Shivakumar ORCID: 0000-0002-7513-3778, Rehme, Anne K., Faymonville, Andrea Maria, Shah, N. Jon ORCID: 0000-0002-8151-6169, Langen, Karl Josef, Goldbrunner, Roland and Grefkes, Christian (2020). Invasive versus non-invasive mapping of the motor cortex. Hum. Brain Mapp., 41 (14). S. 3970 - 3984. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

Precise and comprehensive mapping of somatotopic representations in the motor cortex is clinically essential to achieve maximum resection of brain tumours whilst preserving motor function, especially since the current gold standard, that is, intraoperative direct cortical stimulation (DCS), holds limitations linked to the intraoperative setting such as time constraints or anatomical restrictions. Non-invasive techniques are increasingly relevant with regard to pre-operative risk-assessment. Here, we assessed the congruency of neuronavigated transcranial magnetic stimulation (nTMS) and functional magnetic resonance imaging (fMRI) with DCS. The motor representations of the hand, the foot and the tongue regions of 36 patients with intracranial tumours were mapped pre-operatively using nTMS and fMRI and by intraoperative DCS. Euclidean distances (ED) between hotspots/centres of gravity and (relative) overlaps of the maps were compared. We found significantly smaller EDs (11.4 +/- 8.3 vs. 16.8 +/- 7.0 mm) and better spatial overlaps (64 +/- 38% vs. 37 +/- 37%) between DCS and nTMS compared with DCS and fMRI. In contrast to DCS, fMRI and nTMS mappings were feasible for all regions and patients without complications. In summary, nTMS seems to be the more promising non-invasive motor cortex mapping technique to approximate the gold standard DCS results.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lucas, Carolin WeissUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nettekoven, CharlotteUNSPECIFIEDorcid.org/0000-0002-8944-4681UNSPECIFIED
Neuschmelting, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oros-Peusquens, Ana-MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoffels, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Viswanathan, ShivakumarUNSPECIFIEDorcid.org/0000-0002-7513-3778UNSPECIFIED
Rehme, Anne K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faymonville, Andrea MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shah, N. JonUNSPECIFIEDorcid.org/0000-0002-8151-6169UNSPECIFIED
Langen, Karl JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldbrunner, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grefkes, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-329110
DOI: 10.1002/hbm.25101
Journal or Publication Title: Hum. Brain Mapp.
Volume: 41
Number: 14
Page Range: S. 3970 - 3984
Date: 2020
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1097-0193
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TRANSCRANIAL MAGNETIC STIMULATION; FUNCTIONAL MRI; GLIOMA SURGERY; ELOQUENT BRAIN; GRADE GLIOMAS; NAVIGATED TMS; MAGNETOENCEPHALOGRAPHY; LOCALIZATION; AREAS; ACTIVATIONMultiple languages
Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32911

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