Stripecke, Renata ORCID: 0000-0001-7756-8460, Muenz, Christian, Schuringa, Jan Jacob, Bissig, Karl-Dimiter, Soper, Brian, Meeham, Terrence, Yao, Li-Chin, Di Santo, James P., Brehm, Michael, Rodriguez, Estefania, Wege, Anja Kathrin, Bonnet, Dominique, Guionaud, Silvia, Howard, Kristina E., Kitchen, Scott, Klein, Florian, Saeb-Parsy, Kourosh, Sam, Johannes, Sharma, Amar Deep, Trumpp, Andreas ORCID: 0000-0002-6212-3466, Trusolino, Livio, Bult, Carol and Shultz, Leonard (2020). Innovations, challenges, and minimal information for standardization of humanized mice. EMBO Mol. Med., 12 (7). HOBOKEN: WILEY. ISSN 1757-4684

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Abstract

Mice xenotransplanted with human cells and/or expressing human gene products (also known as humanized mice) recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevantin vivocontext for understanding of human-specific physiology and pathologies. Humanized mice have advanced toward mainstream preclinical models and are now at the forefront of biomedical research. Here, we considered innovations and challenges regarding the reconstitution of human immunity and human tissues, modeling of human infections and cancer, and the use of humanized mice for testing drugs or regenerative therapy products. As the number of publications exploring different facets of humanized mouse models has steadily increased in past years, it is becoming evident that standardized reporting is needed in the field. Therefore, an international community-driven resource called Minimal Information for Standardization of Humanized Mice (MISHUM) has been created for the purpose of enhancing rigor and reproducibility of studies in the field. WithinMISHUM, we propose comprehensive guidelines for reporting critical information generated using humanized mice.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Stripecke, RenataUNSPECIFIEDorcid.org/0000-0001-7756-8460UNSPECIFIED
Muenz, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuringa, Jan JacobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bissig, Karl-DimiterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soper, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meeham, TerrenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yao, Li-ChinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Di Santo, James P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brehm, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez, EstefaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wege, Anja KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonnet, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guionaud, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Howard, Kristina E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kitchen, ScottUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klein, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saeb-Parsy, KouroshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sam, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sharma, Amar DeepUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trumpp, AndreasUNSPECIFIEDorcid.org/0000-0002-6212-3466UNSPECIFIED
Trusolino, LivioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bult, CarolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shultz, LeonardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-329262
DOI: 10.15252/emmm.201708662
Journal or Publication Title: EMBO Mol. Med.
Volume: 12
Number: 7
Date: 2020
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1757-4684
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HEMATOPOIETIC STEM-CELLS; BREAST-CANCER CELLS; LIVER CHIMERIC MICE; MOUSE MODEL; HUMAN HEPATOCYTES; IMMUNE-SYSTEM; HEPATITIS-B; ANTIBODY THERAPY; VIRUS-INFECTION; XENOGRAFTSMultiple languages
Medicine, Research & ExperimentalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32926

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