Universität zu Köln

Weckx, Annelies, Grochau, Kathrin J., Grandoch, Andrea, Backhaus, Tim, Zoeller, Joachim E. and Kreppel, Matthias (2020). Survival outcomes after surgical treatment of oral squamous cell carcinoma. Oral Dis., 26 (7). S. 1432 - 1440. HOBOKEN: WILEY. ISSN 1601-0825

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Abstract

Objective To identify the clinicopathological parameters that influence survival in patients with oral squamous cell carcinoma, in order to allow for the development of individualized surveillance programmes and reduce the delay in diagnosis of recurrence. Materials and Methods Retrospective chart review of 553 patients with a treatment-naive primary oral squamous cell carcinoma, who underwent primarily curative intended surgery. Exclusion criteria were neoadjuvant radio(chemo)therapy, follow-up < 1 year, perioperative death, inoperable disease, synchronous multiple malignancies and inadequate information on clinicopathological parameters. Results The clinicopathological factors that influence overall survival, disease-free survival and locoregional control were calculated. In the multivariate survival analysis, the occurrence of recurrence, presence of extracapsular spread, T- and N-classification were shown to be independent risk factors for overall survival. Conclusion The identification of these risk factors can lead to the development of individualized follow-up programmes based on risk stratification. This allows for the earliest possible diagnosis of relapse which is essential to offer the patient a realistic second treatment chance and to improve survival rates.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weckx, Annelies UNSPECIFIED UNSPECIFIED UNSPECIFIED Grochau, Kathrin J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grandoch, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Backhaus, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-329884
DOI:	10.1111/odi.13422
Journal or Publication Title:	Oral Dis.
Volume:	26
Number:	7
Page Range:	S. 1432 - 1440
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1601-0825
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLINICOPATHOLOGICAL RISK-FACTORS; PERINEURAL INVASION; EXTRACAPSULAR SPREAD; LOCAL RECURRENCE; NECK RECURRENCE; CANCER; CAVITY; SURGERY; NUMBER; NODES Multiple languages Dentistry, Oral Surgery & Medicine Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32988