Universität zu Köln

Scheler, Max, Lehrnbecher, Thomas, Groll, Andreas H., Volland, Ruth, Laws, Hans-Juergen, Ammann, Roland A., Agyeman, Philipp, Attarbaschi, Andishe, Lux, Margaux and Simon, Arne (2020). Management of children with fever and neutropenia: results of a survey in 51 pediatric cancer centers in Germany, Austria, and Switzerland. Infection, 48 (4). S. 607 - 619. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

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Abstract

Purpose Investigation of the current practice of diagnostics and treatment in pediatric cancer patients with febrile neutropenia. Methods On behalf of the German Society for Pediatric Oncology and Hematology and the German Society for Pediatric Infectious Diseases, an Internet-based survey was conducted in 2016 concerning the management of febrile neutropenia in pediatric oncology centers (POC). This survey accompanied the release of the corresponding German guideline to document current practice before its implementation in clinical practice. Results In total, 51 POCs participated (response rate 73%; 43 from Germany, and 4 each from Austria and Switzerland). Identified targets for antimicrobial stewardship concerned blood culture diagnostics, documentation of the time to antibiotics, the use of empirical combination therapy, drug monitoring of aminoglycosides, the time to escalation in patients with persisting fever, minimal duration of IV treatment, sequential oral treatment in patients with persisting neutropenia, indication for and choice of empirical antifungal treatment, and the local availability of a pediatric infectious diseases consultation service. Conclusion This survey provides useful information for local antibiotic stewardship teams to improve the current practice referring to the corresponding national and international guidelines.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scheler, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehrnbecher, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Groll, Andreas H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Volland, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Laws, Hans-Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Ammann, Roland A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Agyeman, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Attarbaschi, Andishe UNSPECIFIED UNSPECIFIED UNSPECIFIED Lux, Margaux UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Arne UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-330230
DOI:	10.1007/s15010-020-01462-z
Journal or Publication Title:	Infection
Volume:	48
Number:	4
Page Range:	S. 607 - 619
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-0973
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL TRANSPLANTATION RECIPIENTS; RISK FEBRILE NEUTROPENIA; 4TH EUROPEAN CONFERENCE; BLOOD CULTURES; LEUKEMIA ECIL-4; THERAPY; ONCOLOGY; GUIDELINES; DEFINITIONS; INFECTIONS Multiple languages Infectious Diseases Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33023