Universität zu Köln

Pennig, Lenhard, Thiele, Frank, Goertz, Lukas, Laukamp, Kai Roman ORCID: 0000-0002-5600-5914, Perkuhn, Michael, Kabbasch, Christoph, Schlamann, Marc, Fink, Gereon Rudolf and Borggrefe, Jan ORCID: 0000-0003-2908-7560 (2020). Comparison of Accuracy of Arrival-Time-Insensitive and Arrival-Time-Sensitive CTP Algorithms for Prediction of Infarct Tissue Volumes. Sci Rep, 10 (1). LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

The purpose of this study was to compare the performance of arrival-time-insensitive (ATI) and arrival-time-sensitive (ATS) computed tomography perfusion (CTP) algorithms in Philips IntelliSpace Portal (v9, ISP) and to investigate optimal thresholds for ATI regarding the prediction of final infarct volume (FIV). Retrospective, single-center study with 54 patients (mean 67.0 +/- 13.1 years, 68.5% male) who received Stroke-CT/CTP-imaging between 2010 and 2018 with occlusion of the middle cerebral artery in the M1-/proximal M2-segment or terminal internal carotid artery. FIV was determined on short-term follow-up imaging in two patient groups: A) not attempted or failed mechanical thrombectomy (MT) and B) successful MT. ATS (default settings) and ATI (full-range of threshold settings regarding FIV prediction) maps were coregistered in 3D with FIV using voxel-wise overlap measurement. Based on an average imaging follow-up of 2.6 +/- 2.1 days, the estimation regarding penumbra (group A, ATI: r=0.63/0.69, ATS: r=0.64) and infarct core (group B, ATI: r=0.60/0.68, ATS: r=0.63) was slightly higher in ATI but the effect was not significant (p>0.05). Regarding ATI, Tmax (AUC 0.9) was the best estimator of the penumbra (group A), CBF relative to the contralateral hemisphere (AUC 0.80) showed the best estimation of the infarct core (group B). There was a broad range of thresholds of optimal ATI settings in both groups. Prediction of FIV with ATI was slightly better compared to ATS. However, this difference was not significant. Since ATI showed a broad range of optimal thresholds, exact thresholds regarding the ATI algorithm should be evaluated in further prospective, clinical studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pennig, Lenhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Goertz, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Laukamp, Kai Roman UNSPECIFIED orcid.org/0000-0002-5600-5914 UNSPECIFIED Perkuhn, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Kabbasch, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlamann, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Borggrefe, Jan UNSPECIFIED orcid.org/0000-0003-2908-7560 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-330265
DOI:	10.1038/s41598-020-66041-6
Journal or Publication Title:	Sci Rep
Volume:	10
Number:	1
Date:	2020
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CEREBRAL-BLOOD-FLOW; ACUTE ISCHEMIC-STROKE; HIGH-RESOLUTION MEASUREMENT; TRACER BOLUS PASSAGES; PERFUSION-CT; COMPUTED-TOMOGRAPHY; DELAY; MRI; DECONVOLUTION; PENUMBRA Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33026