Trickey, Adam ORCID: 0000-0003-3462-2898, May, Margaret T., Gill, M. John, Grabar, Sophie, Vehreschild, Janne, Wit, Ferdinand W. N. M., Bonnet, Fabrice, Cavassini, Matthias, Abgrall, Sophie, Berenguer, Juan, Wyen, Christoph, Reiss, Peter, Grabmeier-Pfistershammer, Katharina, Guest, Jodie L., Shepherd, Leah, Teira, Ramon, Monforte, Antonella d'Arminio, del Amo, Julia, Justice, Amy, Costagliola, Dominique ORCID: 0000-0003-0765-0869 and Sterne, Jonathan A. C. (2020). Cause-specific mortality after diagnosis of cancer among HIV-positive patients: A collaborative analysis of cohort studies. Int. J. Cancer, 146 (11). S. 3134 - 3147. HOBOKEN: WILEY. ISSN 1097-0215

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Abstract

People living with HIV (PLHIV) are more likely than the general population to develop AIDS-defining malignancies (ADMs) and several non-ADMs (NADMs). Information is lacking on survival outcomes and cause-specific mortality after cancer diagnosis among PLHIV. We investigated causes of death within 5 years of cancer diagnosis in PLHIV enrolled in European and North American HIV cohorts starting antiretroviral therapy (ART) 1996-2015, aged >= 16 years, and subsequently diagnosed with cancer. Cancers were grouped: ADMs, viral NADMs and nonviral NADMs. We calculated cause-specific mortality rates (MR) after diagnosis of specific cancers and compared 5-year survival with the UK and France general populations. Among 83,856 PLHIV there were 4,436 cancer diagnoses. Of 603 deaths after ADM diagnosis, 292 (48%) were due to an ADM. There were 467/847 (55%) and 74/189 (39%) deaths that were due to an NADM after nonviral and viral NADM diagnoses, respectively. MR were higher for diagnoses between 1996 and 2005 versus 2006-2015: ADMs 102 (95% CI 92-113) per 1,000 years versus 88 (78-100), viral NADMs 134 (106-169) versus 111 (93-133) and nonviral NADMs 264 (232-300) versus 226 (206-248). Estimated 5-year survival for PLHIV diagnosed with liver (29% [19-39%]), lung (18% [13-23%]) and cervical (75% [63-84%]) cancer was similar to general populations. Survival after Hodgkin's lymphoma diagnosis was lower in PLHIV (75% [67-81%]). Among ART-treated PLHIV diagnosed with cancer, MR and causes of death varied by cancer type, with mortality highest for liver and lung cancers. Deaths within 5 years of NADM diagnoses were more likely to be from cancer than AIDS.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Trickey, AdamUNSPECIFIEDorcid.org/0000-0003-3462-2898UNSPECIFIED
May, Margaret T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gill, M. JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grabar, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wit, Ferdinand W. N. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonnet, FabriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavassini, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abgrall, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berenguer, JuanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wyen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reiss, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grabmeier-Pfistershammer, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guest, Jodie L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shepherd, LeahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teira, RamonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monforte, Antonella d'ArminioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
del Amo, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Justice, AmyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costagliola, DominiqueUNSPECIFIEDorcid.org/0000-0003-0765-0869UNSPECIFIED
Sterne, Jonathan A. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-332515
DOI: 10.1002/ijc.32895
Journal or Publication Title: Int. J. Cancer
Volume: 146
Number: 11
Page Range: S. 3134 - 3147
Date: 2020
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1097-0215
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANTIRETROVIRAL THERAPY; INFECTED INDIVIDUALS; RISK-FACTORS; SURVIVAL; AIDS; TRENDS; COMBINATION; HIV/AIDSMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33251

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