Universität zu Köln

Das, Suman G., Direito, Susana O. L., Waclaw, Bartlomiej, Allen, Rosalind J. and Krug, Joachim ORCID: 0000-0002-2143-6490 (2020). Predictable properties of fitness landscapes induced by adaptational tradeoffs. eLife, 9. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

Fitness effects of mutations depend on environmental parameters. For example, mutations that increase fitness of bacteria at high antibiotic concentration often decrease fitness in the absence of antibiotic, exemplifying a tradeoff between adaptation to environmental extremes. We develop a mathematical model for fitness landscapes generated by such tradeoffs, based on experiments that determine the antibiotic dose-response curves of Escherichia coli strains, and previous observations on antibiotic resistance mutations. Our model generates a succession of landscapes with predictable properties as antibiotic concentration is varied. The landscape is nearly smooth at low and high concentrations, but the tradeoff induces a high ruggedness at intermediate antibiotic concentrations. Despite this high ruggedness, however, all the fitness maxima in the landscapes are evolutionarily accessible from the wild type. This implies that selection for antibiotic resistance in multiple mutational steps is relatively facile despite the complexity of the underlying landscape.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Das, Suman G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Direito, Susana O. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Waclaw, Bartlomiej UNSPECIFIED UNSPECIFIED UNSPECIFIED Allen, Rosalind J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Joachim UNSPECIFIED orcid.org/0000-0002-2143-6490 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-333366
DOI:	10.7554/eLife.55155
Journal or Publication Title:	eLife
Volume:	9
Date:	2020
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Physics > Institut für Biologische Physik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTIBIOTIC-RESISTANCE; COMPENSATORY MUTATIONS; BENEFICIAL MUTATIONS; SIGN EPISTASIS; EVOLUTION; SELECTION; MECHANISMS; DYNAMICS; MODEL Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/33336