Universität zu Köln

Sreenivasan, Krishnamoorthy, Ianni, Alessandro ORCID: 0000-0001-7398-589X, Kuenne, Carsten, Strilic, Boris, Guenther, Stefan, Perdiguero, Eusebio, Krueger, Marcus ORCID: 0000-0003-2008-4582, Spuler, Simone, Offermanns, Stefan, Gomez-del Arco, Pablo ORCID: 0000-0001-6748-7157, Miguel Redondo, Juan, Munoz-Canoves, Pura, Kim, Johnny and Braun, Thomas (2020). Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles. Cell Reports, 31 (7). CAMBRIDGE: CELL PRESS. ISSN 2211-1247

Full text not available from this repository.

Abstract

Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore organ function is not fully understood. Here, we show that a substantial fraction of muscle stem cells (MuSCs) undergo necroptosis because of epigenetic rewiring during chronic skeletal muscle regeneration, which is required for efficient regeneration of dystrophic muscles. Inhibition of necroptosis strongly enhances suppression of MuSC expansion in a non-cell-autonomous manner Prevention of necroptosis in MuSCs of healthy muscles is mediated by the chromatin remodeler CHD4, which directly represses the necroptotic effector Ripk3, while CHD4-dependent Ripk3 repression is dramatically attenuated in dystrophic muscles. Loss of Ripk3 repression by inactivation of Chd4 causes massive necroptosis of MuSCs, abolishing regeneration. Our study demonstrates how programmed cell death in MuSCs is tightly controlled to achieve optimal tissue regeneration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sreenivasan, Krishnamoorthy UNSPECIFIED UNSPECIFIED UNSPECIFIED Ianni, Alessandro UNSPECIFIED orcid.org/0000-0001-7398-589X UNSPECIFIED Kuenne, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Strilic, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Guenther, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Perdiguero, Eusebio UNSPECIFIED UNSPECIFIED UNSPECIFIED Krueger, Marcus UNSPECIFIED orcid.org/0000-0003-2008-4582 UNSPECIFIED Spuler, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Offermanns, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Gomez-del Arco, Pablo UNSPECIFIED orcid.org/0000-0001-6748-7157 UNSPECIFIED Miguel Redondo, Juan UNSPECIFIED UNSPECIFIED UNSPECIFIED Munoz-Canoves, Pura UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Johnny UNSPECIFIED UNSPECIFIED UNSPECIFIED Braun, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-333445
DOI:	10.1016/j.celrep.2020.107652
Journal or Publication Title:	Cell Reports
Volume:	31
Number:	7
Date:	2020
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2211-1247
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SKELETAL-MUSCLE; SATELLITE CELLS; MUSCULAR-DYSTROPHY; CHROMATIN; APOPTOSIS; DEATH; INFLAMMATION; MAINTENANCE; MECHANISMS; INJURY Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/33344