Universität zu Köln

Viswanathan, Shivakumar ORCID: 0000-0002-7513-3778, Abdollahi, Rouhollah O., Wang, Bin A., Grefkes, Christian ORCID: 0000-0002-1656-720X, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Daun, Silvia (2020). A response-locking protocol to boost sensitivity for fMRI-based neurochronometry. Hum. Brain Mapp., 41 (12). S. 3420 - 3439. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

The timeline of brain-wide neural activity relative to a behavioral event is crucial when decoding the neural implementation of a cognitive process. Yet, fMRI assesses neural processes indirectly via delayed and regionally variable hemodynamics. This method-inherent temporal distortion impacts the interpretation of behavior-linked neural timing. Here we describe a novel behavioral protocol that aims at disentangling the BOLD dynamics of the pre- and post-response periods in response time tasks. We tested this response-locking protocol in a perceptual decision-making (random dot) task. Increasing perceptual difficulty produced expected activity increases over a broad network involving the lateral/medial prefrontal cortex and the anterior insula. However, response-locking revealed a previously unreported functional dissociation within this network. preSMA and anterior premotor cortex (prePMV) showed post-response activity modulations while anterior insula and anterior cingulate cortex did not. Furthermore, post-response BOLD activity at preSMA showed a modulation in timing but not amplitude while this pattern was reversed at prePMV. These timeline dissociations with response-locking thus revealed three functionally distinct sub-networks in what was seemingly one shared distributed network modulated by perceptual difficulty. These findings suggest that our novel response-locked protocol could boost the timing-related sensitivity of fMRI.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Viswanathan, Shivakumar UNSPECIFIED orcid.org/0000-0002-7513-3778 UNSPECIFIED Abdollahi, Rouhollah O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Bin A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Daun, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-334151
DOI:	10.1002/hbm.25026
Journal or Publication Title:	Hum. Brain Mapp.
Volume:	41
Number:	12
Page Range:	S. 3420 - 3439
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PERCEPTUAL DECISION-MAKING; EVENT-RELATED FMRI; EVIDENCE ACCUMULATION; MENTAL CHRONOMETRY; PARIETAL CORTEX; FUNCTIONAL MRI; SEPARATING PROCESSES; MOTOR CORTEX; TIME; TRIAL Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33415