Universität zu Köln

Meyer, Thomas, Rothe, Isabel, Staab, Julia, Deter, Hans-Christian ORCID: 0000-0001-8575-4570, Fangauf, Stella V., Hamacher, Stefanie ORCID: 0000-0003-2158-9101, Hellmich, Martin, Juenger, Jana, Ladwig, Karl-Heinz, Michal, Matthias, Petrowski, Katja, Ronel, Joram, Soellner, Wolfgang, Weber, Cora, de Zwaan, Martina, Williams, Redford B., Albus, Christian and Herrmann-Lingen, Christoph (2020). Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease. Biochem. Genet., 58 (4). S. 631 - 649. NEW YORK: SPRINGER/PLENUM PUBLISHERS. ISSN 1573-4927

Full text not available from this repository.

Abstract

Genetic variations affecting the course of depressive symptoms in patients with coronary artery disease (CAD) have not yet been well studied. Therefore, we set out to investigate whether distinct haplotypes of the two insertion/deletion polymorphisms in the serotonin-transporter-linked polymorphic region (5-HTTLPR) and the angiotensin I-converting enzyme (ACE) gene located on chromosome 17 can be identified as risk factors for trajectories of depression. Clinical and genotyping data were derived from 507 depressed CAD patients participating in the randomized, controlled, multicenter Stepwise Psychotherapy Intervention for Reducing Risk in Coronary Artery Disease (SPIRR-CAD) trial, of whom the majority had an acute cardiac event before study inclusion. Depression scores on the Hospital Anxiety and Depression Scale (HADS) were assessed at baseline and at five follow-up time points up to 2 years after study entrance. At baseline, depression scores did not significantly differ between patients carrying the risk haplotype ACE D/D, 5-HTTLPR I/I (n = 46) and the non-risk haplotypes (n = 461, 10.9 +/- 2.7 versus 10.4 +/- 2.5, p = 0.254). HADS-depression scores declined from study inclusion during the first year irrespective of the genotype. At each follow-up time point, HADS-depression scores were significantly higher in ACE D/D, 5-HTTLPR I/I carriers than in their counterparts. Two years after study inclusion, the mean HADS depression score remained 1.8 points higher in patients with the risk haplotype as compared to subjects not carrying this haplotype (9.9 +/- 4.2 versus 8.1 +/- 4.0, p = 0.009). In summary, the presence of the ACE D/D, 5-HTTLPR I/I haplotype may be a vulnerability factor for comorbid depressive symptoms in CAD patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Meyer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothe, Isabel UNSPECIFIED UNSPECIFIED UNSPECIFIED Staab, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Deter, Hans-Christian UNSPECIFIED orcid.org/0000-0001-8575-4570 UNSPECIFIED Fangauf, Stella V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamacher, Stefanie UNSPECIFIED orcid.org/0000-0003-2158-9101 UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Juenger, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Ladwig, Karl-Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Michal, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Petrowski, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Ronel, Joram UNSPECIFIED UNSPECIFIED UNSPECIFIED Soellner, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Cora UNSPECIFIED UNSPECIFIED UNSPECIFIED de Zwaan, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Williams, Redford B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Albus, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrmann-Lingen, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-334354
DOI:	10.1007/s10528-020-09967-w
Journal or Publication Title:	Biochem. Genet.
Volume:	58
Number:	4
Page Range:	S. 631 - 649
Date:	2020
Publisher:	SPRINGER/PLENUM PUBLISHERS
Place of Publication:	NEW YORK
ISSN:	1573-4927
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEPWISE PSYCHOTHERAPY INTERVENTION; INSERTION DELETION POLYMORPHISM; HOSPITAL ANXIETY; MAJOR DEPRESSION; I/D POLYMORPHISM; RANDOMIZED-TRIAL; NEGATIVE AFFECT; REDUCING RISK; SPIRR-CAD; ASSOCIATION Multiple languages Biochemistry & Molecular Biology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33435