Universität zu Köln

Tscherpel, Caroline, Hensel, Lukas, Lemberg, Katharina, Vollmer, Mattias, Volz, Lukas J., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Grefkes, Christian ORCID: 0000-0002-1656-720X (2020). The differential roles of contralesional frontoparietal areas in cortical reorganization after stroke. Brain Stimul., 13 (3). S. 614 - 625. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1876-4754

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Abstract

Background: Studies examining the contribution of contralesional brain regions to motor recovery after stroke have revealed conflicting results comprising both supporting and disturbing influences. Especially the relevance of contralesional brain regions beyond primary motor cortex (M1) has rarely been studied, particularly concerning the temporal dynamics post-stroke. Methods: We, therefore, used online transcranial magnetic stimulation (TMS) interference to longitudinally assess the role of contralesional (right) frontoparietal areas for recovery of hand motor function after left hemispheric stroke: contralesional M1, contralesional dorsal premotor cortex (dPMC), and contralesional anterior intraparietal sulcus (IPS). Fourteen stroke patients and sixteen age-matched healthy subjects performed motor tasks of varying complexity with their (paretic) right hand. Motor performance was quantified using three-dimensional kinematic data. All patients were assessed twice, (i) in the first week, and (ii) after more than three months post-stroke. Results: While we did not observe a significant effect of TMS interference on movement kinematics following the stimulation of contralesional M1 and dPMC in the first week post-stroke, we found improvements of motor performance upon interference with contralesional IPS across motor tasks early after stroke, an effect that persisted into the later phase. By contrast, for dPMC, TMS-induced deterioration of motor performance was only evident three months post-stroke, suggesting that a supportive role of contralesional premotor cortex might evolve with reorganization. Conclusion: We here highlight time-sensitive and region-specific effects of contralesional frontoparietal areas after left hemisphere stroke, which may influence on neuromodulation regimes aiming at supporting recovery of motor function post-stroke. (C) 2020 The Author(s). Published by Elsevier Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tscherpel, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Hensel, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemberg, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Vollmer, Mattias UNSPECIFIED UNSPECIFIED UNSPECIFIED Volz, Lukas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-335321
DOI:	10.1016/j.brs.2020.01.016
Journal or Publication Title:	Brain Stimul.
Volume:	13
Number:	3
Page Range:	S. 614 - 625
Date:	2020
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1876-4754
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; IPSILATERAL MOTOR CORTEX; INTRAPARIETAL SULCUS; MOVEMENT KINEMATICS; FUNCTIONAL-ANATOMY; NEURAL ACTIVITY; RECOVERY; BRAIN; CONNECTIVITY; HEMISPHERE Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33532