Universität zu Köln

Loreck, Niklas, Adler, Werner, Siebelmann, Sebastian, Rokohl, Alexander C., Heindl, Ludwig M., Cursiefen, Claus, Bachmann, Bjoern O. and Matthaei, Mario (2020). Morning Myopic Shift and Glare in Advanced Fuchs Endothelial Corneal Dystrophy. Am. J. Ophthalmol., 213. S. 69 - 76. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-1891

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Abstract

PURPOSE: Impaired subjective morning visual acuity with improvement of symptoms during the day is pathognomonic for corneal endothelial dysfunction in advanced Fuchs endothelial corneal dystrophy (FECD). This study aimed to analyze the daily fluctuations of corneal thickness, refraction, and (glare) visual acuity in advanced FECD. DESIGN: Prospective cohort study. METHODS: Patients with advanced FECD (FECD group) and patients with normal cornea (control group) were enrolled. Routine clinical examination was performed using slit-lamp biomicroscopy, funduscopy, and macular optical coherence tomography. In addition, assessment using corneal Scheimpflug tomography (Pentacam), refraction, corrected distance visual acuity (CDVA), and glare CDVA was performed at 4 PM (afternoon) and the following day at 8 AM (morning). RESULTS: A total of 29 FECD eyes and 22 control eyes were included. Diurnal variations from afternoon to morning were Delta corneal thickness (apex) +/- standard deviation (SD) 41.45 +/- 34.1 mu m (P < .001, FECD group) and 5.5 +/- 6.72 mu m (P = .001, control group); Delta spherical equivalent +/- SD - 0.64 +/- 0.6 diopters (D) < .001, FECD group) and - 0.01 +/- 0.50 D (P = .461, control group); Delta total corneal refractive power +/- SD 0.60 +/- 0.83 D (P = .001, FECD group) and - 0.01 +/- 0.49 D (P = .602, control group), Delta CDVA +/- SD 0.15 +/- 0.18 logarithm of minimal angle of resolution (logMAR) (P < .001, FECD group) and 0.02 +/- 0.04 logMAR (P = .174, control group), Delta CDVA glare +/- SD 0.34 +/- 0.25 logMAR (P < .001, FECD group) and 0.05 +/- 0.11 logMAR (P = .106, control group). CONCLUSION: A morning myopic shift and increased glare paralleling increased corneal thickness may particularly contribute to subjective visual impairment in advanced FECD in the first hours after awaking. This should be taken into account during assessment and surgical decision-making in patients with FECD. (C) 2020 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Loreck, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Adler, Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebelmann, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Rokohl, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Bjoern O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Matthaei, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-335629
DOI:	10.1016/j.ajo.2020.01.011
Journal or Publication Title:	Am. J. Ophthalmol.
Volume:	213
Page Range:	S. 69 - 76
Date:	2020
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-1891
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HYDRATION CONTROL; DIURNAL-VARIATIONS; EDEMA Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33562