Universität zu Köln

Lanternier, Fanny, Seidel, Danila, Pagano, Livio, Styczynski, Jan ORCID: 0000-0002-3158-119X, Mikulska, Malgorzata, Pulcini, Celine, Maertens, Johan ORCID: 0000-0003-4257-5980, Munoz, Patricia, Garcia-Vidal, Carol, Rijnders, Bart, Arendrup, Maiken Cavling, Sabino, Raquel, Verissimo, Cristina, Gaustad, Peter, Klimko, Nikolay, Arikan-Akdagli, Sevtap, Arsic, Valentina, Barac, Aleksandra ORCID: 0000-0002-0132-2277, Skiada, Anna, Klingspor, Lena, Herbrecht, Raoul, Donnelly, Peter, Cornely, Oliver A., Lass-Floerl, Cornelia and Lortholary, Olivier (2020). Invasive pulmonary aspergillosis treatment duration in haematology patients in Europe: An EFISG, IDWP-EBMT, EORTC-IDG and SEIFEM survey. Mycoses, 63 (5). S. 420 - 430. HOBOKEN: WILEY. ISSN 1439-0507

Full text not available from this repository.

Abstract

Invasive pulmonary aspergillosis (IPA) optimal duration of antifungal treatment is not known. In a joint effort, four international scientific societies/groups performed a survey to capture current practices in European haematology centres regarding management of IPA. We conducted a cross-sectional internet-based questionnaire survey in 2017 to assess practices in sixteen European countries concerning IPA management in haematology patients including tools to evaluate treatment response, duration and discontinuation. The following four groups/societies were involved in the project: European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study Group (EFISG), Infectious Diseases Working Party-European Society for Blood and Bone Marrow Transplantation (IDWP-EBMT), European Organisation for Research and Treatment-Infectious Disease group (EORTC-IDG) and Sorveglianza Epidemiologica Infezioni nelle Emopatie (SEIFEM). A total of 112 physicians from 14/16 countries answered the survey. Galactomannan antigen was available in serum and bronchoalveolar lavage in most centres (106/112 [95%] and 97/112 [87%], respectively), quantitative Aspergillus PCR in 27/112 (24%) centres, beta-D-glucan in 24/112 (21%) and positron emission tomography in 50/112 (45%). Treatment duration differed between haematological malignancies, with a median duration of 6 weeks [IQR 3-12] for patients with AML, 11 [4-12] for patients with allogenic stem cell transplantation and GvHD and 6 [3-12] for patients with lymphoproliferative disease. Treatment duration significantly differed according to country. Essential IPA biomarkers are not available in all European countries, and treatment duration is highly variable according to country. It will be important to provide guidelines to help with IPA treatment cessation with algorithms according to biomarker availability.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lanternier, Fanny UNSPECIFIED UNSPECIFIED UNSPECIFIED Seidel, Danila UNSPECIFIED UNSPECIFIED UNSPECIFIED Pagano, Livio UNSPECIFIED UNSPECIFIED UNSPECIFIED Styczynski, Jan UNSPECIFIED orcid.org/0000-0002-3158-119X UNSPECIFIED Mikulska, Malgorzata UNSPECIFIED UNSPECIFIED UNSPECIFIED Pulcini, Celine UNSPECIFIED UNSPECIFIED UNSPECIFIED Maertens, Johan UNSPECIFIED orcid.org/0000-0003-4257-5980 UNSPECIFIED Munoz, Patricia UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia-Vidal, Carol UNSPECIFIED UNSPECIFIED UNSPECIFIED Rijnders, Bart UNSPECIFIED UNSPECIFIED UNSPECIFIED Arendrup, Maiken Cavling UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabino, Raquel UNSPECIFIED UNSPECIFIED UNSPECIFIED Verissimo, Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaustad, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Klimko, Nikolay UNSPECIFIED UNSPECIFIED UNSPECIFIED Arikan-Akdagli, Sevtap UNSPECIFIED UNSPECIFIED UNSPECIFIED Arsic, Valentina UNSPECIFIED UNSPECIFIED UNSPECIFIED Barac, Aleksandra UNSPECIFIED orcid.org/0000-0002-0132-2277 UNSPECIFIED Skiada, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Klingspor, Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Herbrecht, Raoul UNSPECIFIED UNSPECIFIED UNSPECIFIED Donnelly, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lass-Floerl, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Lortholary, Olivier UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-335978
DOI:	10.1111/myc.13056
Journal or Publication Title:	Mycoses
Volume:	63
Number:	5
Page Range:	S. 420 - 430
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0507
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language THERAPY; ISAVUCONAZOLE; GALACTOMANNAN; VORICONAZOLE; GUIDELINES; MANAGEMENT; DIAGNOSIS; DISEASES; VOLUME Multiple languages Dermatology; Mycology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33597