Beyer, Leonie, Nitschmann, Alexander, Barthel, Henryk, van Eimeren, Thilo, Unterrainer, Marcus, Sauerbeck, Julia, Marek, Ken, Song, Mengmeng, Palleis, Carla, Respondek, Gesine, Hammes, Jochen, Barbe, Michael T., Onur, Oezguer, Jessen, Frank, Saur, Dorothee ORCID: 0000-0002-1808-0913, Schroeter, Matthias L., Rumpf, Jost-Julian, Rullmann, Michael ORCID: 0000-0002-2683-9432, Schildan, Andreas, Patt, Marianne, Neumaier, Bernd, Barret, Olivier ORCID: 0000-0003-4247-184X, Madonia, Jennifer, Russell, David S., Stephens, Andrew W., Roeber, Sigrun, Herms, Jochen, Boetzel, Kai, Levin, Johannes ORCID: 0000-0001-5092-4306, Classen, Joseph ORCID: 0000-0001-7182-6967, Hoeglinger, Guenter U., Bartenstein, Peter, Villemagne, Victor, Drzezga, Alexander, Seibyl, John, Sabri, Osama ORCID: 0000-0002-6425-3504 and Brendel, Matthias (2020). Early-phase [F-18]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury. Eur. J. Nucl. Med. Mol. Imaging, 47 (12). S. 2911 - 2923. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Purpose Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several beta-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [F-18]PI-2620 as a potential substitute for [F-18]fluorodeoxyglucose ([F-18]FDG). Methods Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson's disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [F-18]PI-2620 tau-PET (0-60 min p.i.) and static [F-18]FDG-PET (30-50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R-1) of [F-18]PI-2620-PET were correlated with corresponding quantification of [F-18]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [F-18]PI-2620 tau-PET and [F-18]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers. Results Highest agreement with [F-18]FDG-PET quantification was reached for [F-18]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5-2.5 min SUVr & R-1) displayed strong agreement in all cortical target regions for global mean (R-SUVr 0.76, R-R1 = 0.77) and cerebellar normalization (R-SUVr 0.68, R-R1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [F-18]FDG-PET. There were no relevant differences between more and less experienced readers. Conclusion Early-phase imaging of [F-18]PI-2620 can serve as a surrogate biomarker for neuronal injury. Dynamic imaging or a dual time-point protocol for tau-PET imaging could supersede additional [F-18]FDG-PET imaging by indexing both the distribution of tau and the extent of neuronal injury.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Beyer, LeonieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nitschmann, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barthel, HenrykUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Eimeren, ThiloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Unterrainer, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sauerbeck, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marek, KenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Song, MengmengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palleis, CarlaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Respondek, GesineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hammes, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Onur, OezguerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saur, DorotheeUNSPECIFIEDorcid.org/0000-0002-1808-0913UNSPECIFIED
Schroeter, Matthias L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rumpf, Jost-JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rullmann, MichaelUNSPECIFIEDorcid.org/0000-0002-2683-9432UNSPECIFIED
Schildan, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patt, MarianneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumaier, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barret, OlivierUNSPECIFIEDorcid.org/0000-0003-4247-184XUNSPECIFIED
Madonia, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Russell, David S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stephens, Andrew W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roeber, SigrunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herms, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boetzel, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Levin, JohannesUNSPECIFIEDorcid.org/0000-0001-5092-4306UNSPECIFIED
Classen, JosephUNSPECIFIEDorcid.org/0000-0001-7182-6967UNSPECIFIED
Hoeglinger, Guenter U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartenstein, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villemagne, VictorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seibyl, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabri, OsamaUNSPECIFIEDorcid.org/0000-0002-6425-3504UNSPECIFIED
Brendel, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-336668
DOI: 10.1007/s00259-020-04788-w
Journal or Publication Title: Eur. J. Nucl. Med. Mol. Imaging
Volume: 47
Number: 12
Page Range: S. 2911 - 2923
Date: 2020
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1619-7089
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
POSITRON-EMISSION-TOMOGRAPHY; REFERENCE TISSUE MODEL; IMAGESMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33666

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