Universität zu Köln

Joisten, Niklas, Schumann, Moritz, Schenk, Alexander, Walzik, David ORCID: 0000-0002-9577-1435, Freitag, Nils ORCID: 0000-0002-4415-5421, Knoop, Andre, Thevis, Mario, Bloch, Wilhelm and Zimmer, Philipp (2020). Acute hypertrophic but not maximal strength loading transiently enhances the kynurenine pathway towards kynurenic acid. Eur. J. Appl. Physiol., 120 (6). S. 1429 - 1437. NEW YORK: SPRINGER. ISSN 1439-6327

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Abstract

Purpose Due to distinct immuno- and neuro-modulatory properties, growing research interest focuses on exercise-induced alterations of the kynurenine (KYN) pathway in healthy and clinical populations. To date, knowledge about the impact of different acute strength exercise modalities on the KYN pathway is scarce. Therefore, we investigated the acute effects of hypertrophic (HYP) compared to maximal (MAX) strength loadings on the KYN pathway regulation. Methods Blood samples of twelve healthy males (mean age and weight: 23.5 +/- 3.2 years; 77.5 +/- 7.5 kg) were collected before (T-0), immediately after (T-1), and 1 h after completion (T-2) of HYP (5 sets with 10 repetitions at 80% of 1RM) and MAX (15 sets with 1RM) loadings performed in a randomized cross-over design. Serum concentrations of tryptophan (TRP), KYN, kynurenic acid (KA), and quinolinic acid (QA) were assessed using high-performance liquid chromatography. Results The KA/KYN ratio increased from T-0 to T-1 (p = 0.01) and decreased from T-1 to T-2 (p = 0.011) in HYP, while it was maintained within MAX. Compared to MAX, serum concentrations of KA were greater in HYP at T-1 (p = 0.014). Moreover, the QA/KA ratio was significantly lower in HYP than in MAX at T-1 (p = 0.002). Conclusion Acute HYP loading led to increases in the metabolic flux yielding KA, thereby possibly promoting immunosuppression and neuroprotection. Our findings emphasize the potential of acute HYP exercise as short-term modulator of KYN pathway downstream to KA in healthy males and need to be proven in other samples.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Joisten, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumann, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Walzik, David UNSPECIFIED orcid.org/0000-0002-9577-1435 UNSPECIFIED Freitag, Nils UNSPECIFIED orcid.org/0000-0002-4415-5421 UNSPECIFIED Knoop, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-336847
DOI:	10.1007/s00421-020-04375-9
Journal or Publication Title:	Eur. J. Appl. Physiol.
Volume:	120
Number:	6
Page Range:	S. 1429 - 1437
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1439-6327
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SKELETAL-MUSCLE; EXERCISE; METABOLISM; STRESS Multiple languages Physiology; Sport Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33684