Universität zu Köln

Jenks, Jeffrey D., Seidel, Danila, Cornely, Oliver A., Chen, Sharon, van Hal, Sebastiaan ORCID: 0000-0001-5852-4155, Kauffman, Carol, Miceli, Marisa H., Heinemann, Melina ORCID: 0000-0001-7762-4696, Christner, Martin, Jover Saenz, Alfredo, Burchardt, Alexander, Kemmerling, Bjoern, Herbrecht, Raoul, Steinmann, Joerg, Shoham, Shmuel, Graeber, Sandra, Pagano, Livio, Deeren, Dries, Slavin, Monica A. and Hoenigl, Martin ORCID: 0000-0002-1653-2824 (2020). Clinical characteristics and outcomes of invasive Lomentospora prolificans infections: Analysis of patients in the FungiScope (R) registry. Mycoses, 63 (5). S. 437 - 443. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

Objectives Invasive fungal infections caused by Lomentospora prolificans are associated with very high mortality rates and can be challenging to treat given pan-drug resistance to available antifungal agents. The objective of this study was to describe the clinical presentation and outcomes in a cohort of patients with invasive L prolificans infections. Methods We performed a retrospective review of medical records of patients with invasive L prolificans infection in the FungiScope(R) registry of rare invasive fungal infections. Patients diagnosed between 01 January 2008 and 09 September 2019 were included in for analysis. Results The analysis included 41 patients with invasive L prolificans infection from eight different countries. Haematological/oncological malignancies were the most frequent underlying disease (66%), disseminated infection was frequent (61%), and the lung was the most commonly involved organ (44%). Most infections (59%) were breakthrough infections. Progression/deterioration/treatment failure was observed in 23/40 (58%) of patients receiving antifungal therapy. In total, 21/41 (51%) patients, and 77% of patients with underlying haematological/oncological malignancy, had a fatal outcome attributed to invasive fungal infection. Combination antifungal therapy was frequent (24/40) and associated with improved survival. In particular, treatment regimens including terbinafine were significantly associated with higher treatment success at final assessment (P = .012), with a positive trend observed for treatment regimens that included voriconazole (P = .054). Conclusions Lomentospora prolificans infections were associated with mortality rates of 77% and above in patients with underlying haematological/oncological malignancies and those with disseminated infections. While combination therapy is the preferred option for now, the hope lies with novel antifungals currently under development.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jenks, Jeffrey D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seidel, Danila UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Sharon UNSPECIFIED UNSPECIFIED UNSPECIFIED van Hal, Sebastiaan UNSPECIFIED orcid.org/0000-0001-5852-4155 UNSPECIFIED Kauffman, Carol UNSPECIFIED UNSPECIFIED UNSPECIFIED Miceli, Marisa H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinemann, Melina UNSPECIFIED orcid.org/0000-0001-7762-4696 UNSPECIFIED Christner, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Jover Saenz, Alfredo UNSPECIFIED UNSPECIFIED UNSPECIFIED Burchardt, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Kemmerling, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Herbrecht, Raoul UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinmann, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Shoham, Shmuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Graeber, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Pagano, Livio UNSPECIFIED UNSPECIFIED UNSPECIFIED Deeren, Dries UNSPECIFIED UNSPECIFIED UNSPECIFIED Slavin, Monica A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoenigl, Martin UNSPECIFIED orcid.org/0000-0002-1653-2824 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-337077
DOI:	10.1111/myc.13067
Journal or Publication Title:	Mycoses
Volume:	63
Number:	5
Page Range:	S. 437 - 443
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0507
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MYCOSES STUDY-GROUP; MOLD INFECTIONS; ANTIFUNGAL SUSCEPTIBILITY; SCEDOSPORIUM-APIOSPERMUM; TRANSPLANT RECIPIENTS; EUROPEAN-ORGANIZATION; COMBINATION; TERBINAFINE; ASPERGILLUS; ISAVUCONAZOLE Multiple languages Dermatology; Mycology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33707