Universität zu Köln

Lang, Andras ORCID: 0000-0002-3329-2359, Kumar, Amit, Jirschitzka, Jan ORCID: 0000-0003-1007-4700, Bordusa, Frank, Ohlenschlaeger, Oliver ORCID: 0000-0002-6428-4423 and Wiedemann, Christoph (2020). H-1, C-13, and N-15 Backbone assignments of the human brain and acute leukemia cytoplasmic (BAALC) protein. Biomol. NMR Assign., 14 (2). S. 163 - 169. DORDRECHT: SPRINGER. ISSN 1874-270X

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Abstract

The brain and acute leukemia cytoplasmic (BAALC; UniProt entry Q8WXS3) is a 180-residue-long human protein having six known isoforms. BAALC is expressed in either hematopoietic or neuroectodermal cells and its specific function is still to be revealed. However, as a presumably membrane-anchored protein at the cytoplasmic side it is speculated that BAALC exerts its function at the postsynaptic densities of certain neurons and might play a role in developing cytogenetically normal acute myeloid leukemia (CN-AML) when it is highly overexpressed by myeloid or lymphoid progenitor cells. In order to better understand the physiological role of BAALC and to provide the basis for a further molecular characterization of BAALC, we report here the H-1, C-13, and N-15 resonance assignments for the backbone nuclei of its longest hematopoietic isoform (isoform 1). In addition, we present a H-1(N) and N-15(H) chemical shift comparison of BAALC with its shortest, neuroectodermal isoform (isoform 6) which shows only minor changes in the H-1 and N-15 chemical shifts.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lang, Andras UNSPECIFIED orcid.org/0000-0002-3329-2359 UNSPECIFIED Kumar, Amit UNSPECIFIED UNSPECIFIED UNSPECIFIED Jirschitzka, Jan UNSPECIFIED orcid.org/0000-0003-1007-4700 UNSPECIFIED Bordusa, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Ohlenschlaeger, Oliver UNSPECIFIED orcid.org/0000-0002-6428-4423 UNSPECIFIED Wiedemann, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-337702
DOI:	10.1007/s12104-020-09938-7
Journal or Publication Title:	Biomol. NMR Assign.
Volume:	14
Number:	2
Page Range:	S. 163 - 169
Date:	2020
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	1874-270X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE MYELOID-LEUKEMIA; SECONDARY STRUCTURE; NMR-SPECTROSCOPY; ALPHA; SENSITIVITY; PREDICTION; BETA Multiple languages Biophysics; Spectroscopy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33770