Universität zu Köln

Scheiblich, Hannah, Trombly, Melanie, Ramirez, Alfredo ORCID: 0000-0003-4991-763X and Heneka, Michael T. (2020). Neuroimmune Connections in Aging and Neurodegenerative Diseases. Trends Immunol., 41 (4). S. 300 - 313. OXFORD: ELSEVIER SCI LTD. ISSN 1471-4981

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Abstract

In recent years, the inter-relationship between the innate immune system and the central nervous system (CNS) has moved to the forefront of biomedical research, with the discovery that these two physiological systems modulate each other by a steady mutual interaction. During normal brain aging, but also under certain pathological conditions, this crosstalk can go beyond physiological control, resulting in an unresolved inflammatory response of the CNS-resident immune cells that might initiate and propagate the progression of severe tissue damage and neurodegeneration. In this review, we focus on the impact of CNS-resident cells of the innate immune system for the development of neurodegenerative diseases, review immune pathway genes that have been identified, and discuss the vicious cycle between inflammation and neurodegeneration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scheiblich, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Trombly, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramirez, Alfredo UNSPECIFIED orcid.org/0000-0003-4991-763X UNSPECIFIED Heneka, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-339452
DOI:	10.1016/j.it.2020.02.002
Journal or Publication Title:	Trends Immunol.
Volume:	41
Number:	4
Page Range:	S. 300 - 313
Date:	2020
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1471-4981
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; MISSENSE MUTATIONS; AMYLOID-BETA; IMMUNE; GENE; MICROGLIA; ONSET; CELLS; AGE Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33945