Schroeder, Lars, Hellmund, Astrid, Gembruch, Ulrich ORCID: 0000-0001-8284-4669 and Merz, Waltraut Maria (2020). Amniotic fluid embolism-associated coagulopathy: a single-center observational study. Arch. Gynecol. Obstet., 301 (4). S. 923 - 930. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-0711
Full text not available from this repository.Abstract
Introduction Amniotic fluid embolism (AFE) continues to be a rare, enigmatic condition with high maternal mortality. It is characterized by cardiovascular compromise, loss of consciousness or other neurologic symptoms, and coagulopathy. The latter is usually treated according to existing protocols for consumptive coagulopathy. Methods Serial analyses of a panel of hemostaseological parameters were performed in three consecutive cases of AFE that occurred at our institution. Results All mothers and neonates survived without major sequelae. Disproportionately low levels of fibrinogen and factor five, and exorbitantly elevated d-dimers were present in all cases, whereas markers of consumptive coagulopathy, platelets and antithrombin in particular, were only slightly reduced. Discussion Our results support hyperfibrinolysis as contributing factor of AFE-associated coagulopathy. We, therefore, propose a treatment algorithm which includes early use of tranexamic acid and transfusion of red blood cells and fresh frozen plasma, adding fibrinogen if hemostasis is not readily achieved.
Item Type: | Journal Article | ||||||||||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-339542 | ||||||||||||||||||||
DOI: | 10.1007/s00404-020-05466-w | ||||||||||||||||||||
Journal or Publication Title: | Arch. Gynecol. Obstet. | ||||||||||||||||||||
Volume: | 301 | ||||||||||||||||||||
Number: | 4 | ||||||||||||||||||||
Page Range: | S. 923 - 930 | ||||||||||||||||||||
Date: | 2020 | ||||||||||||||||||||
Publisher: | SPRINGER HEIDELBERG | ||||||||||||||||||||
Place of Publication: | HEIDELBERG | ||||||||||||||||||||
ISSN: | 1432-0711 | ||||||||||||||||||||
Language: | English | ||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/33954 |
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