Universität zu Köln

Henssler, Jonathan ORCID: 0000-0001-8123-5853, Brandt, Lasse, Mueller, Martin, Liu, Shuyan, Montag, Christiane ORCID: 0000-0002-3307-276X, Sterzer, Philipp and Heinz, Andreas ORCID: 0000-0001-5405-9065 (2020). Migration and schizophrenia: meta-analysis and explanatory framework. Eur. Arch. Psych. Clin. Neurosci., 270 (3). S. 325 - 336. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-8491

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Abstract

Systematic reviews and meta-analyses suggest that there are increased rates of schizophrenia and related psychoses in first- and second-generation migrants and refugees. Here, we present a meta-analysis on the incidence of non-affective psychotic disorders among first- and second-generation migrants. We found substantial evidence for an increased relative risk of incidence among first- and second-generation migrants compared to the native population. As heterogeneity of included studies was high, effect estimates should be interpreted with caution and as guiding values rather than exact risk estimates. We interpret our findings in the context of social exclusion and isolation stress, and provide an explanatory framework that links cultural differences in verbal communication and experienced discrimination with the emergence of psychotic experiences and their neurobiological correlates. In this context, we discuss studies observing stress-dependent alterations of dopamine neurotransmission in studies among migrants versus non-migrants as well as in subjects with psychotic disorders. We suggest that social stress effects can impair contextualization of the meaning of verbal messages, which can be accounted for in Bayesian terms by a reduced precision of prior beliefs relative to sensory data, causing increased prediction errors and resulting in a shift towards the literal or concrete meaning of words. Compensatory alterations in higher-level beliefs, e.g., in the form of generalized interpretations of ambiguous interactions as hostile behavior, may contribute to psychotic experiences in migrants. We thus suggest that experienced discrimination and social exclusion is at the core of increased rates of psychotic experiences in subjects with a migration background.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Henssler, Jonathan UNSPECIFIED orcid.org/0000-0001-8123-5853 UNSPECIFIED Brandt, Lasse UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Shuyan UNSPECIFIED UNSPECIFIED UNSPECIFIED Montag, Christiane UNSPECIFIED orcid.org/0000-0002-3307-276X UNSPECIFIED Sterzer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinz, Andreas UNSPECIFIED orcid.org/0000-0001-5405-9065 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-339748
DOI:	10.1007/s00406-019-01028-7
Journal or Publication Title:	Eur. Arch. Psych. Clin. Neurosci.
Volume:	270
Number:	3
Page Range:	S. 325 - 336
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-8491
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDUCED DOPAMINE RELEASE; ETHNIC-MINORITY GROUPS; PSYCHOTIC DISORDERS; 2ND-GENERATION IMMIGRANTS; MENTAL-DISORDERS; MIGRANT GROUPS; RISK-FACTOR; PSYCHIATRIC-DISORDERS; SOCIAL ADVERSITY; INCREASED RATES Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33974