Alamzadeh, Zahra, Beik, Jaber, Mirrahimi, Mehraban, Shakeri-Zadeh, Ali ORCID: 0000-0002-2847-9223, Ebrahimi, Fatemeh, Komeili, Ali, Ghalandari, Behafarid, Ghaznavi, Habib, Kamrava, S. Kamran and Moustakis, Christos (2020). Gold nanoparticles promote a multimodal synergistic cancer therapy strategy by co-delivery of thermo-chemo-radio therapy. Eur. J. Pharm. Sci., 145. AMSTERDAM: ELSEVIER. ISSN 1879-0720

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Abstract

Multimodal cancer therapy has become a new trend in clinical oncology due to potential generation of synergistic therapeutic effects. Herein, we propose a multifunctional nanoplatform comprising alginate hydrogel co-loaded with cisplatin and gold nanoparticles (abbreviated as ACA) for triple combination of photothermal therapy, chemotherapy and radiotherapy (thermo-chemo-radio therapy). The therapeutic potential of ACA was assessed in combination with 532 nm laser and 6 MV X-ray against KB human mouth epidermal carcinoma cells. The results demonstrated that tri-modal thermo-chemo-radio therapy using ACA induced a superior anticancer efficacy than mono- or bi-modality treatments. The intracellular reactive oxygen species (ROS) level in KB cells treated with tri-modal therapy was increased by 4.4-fold compared to untreated cells. The gene expression analysis demonstrated the up-regulation of Box pro-apoptotic factor (by 4.5-fold) and the down-regulation of Bcl-2 anti-apoptotic factor (by 0.3-fold). The massive cell injury and the appearance of morphological characteristics of apoptosis were also evident in the micrograph of KB cells caused by thermo-chemo-radio therapy. Therefore, ACA nanocomplex can be offered as a promising platform to combine photothermal therapy, chemotherapy and radiotherapy, thereby affording an opportunity for combating chemo- and radio-resistant tumors.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Alamzadeh, ZahraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beik, JaberUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mirrahimi, MehrabanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shakeri-Zadeh, AliUNSPECIFIEDorcid.org/0000-0002-2847-9223UNSPECIFIED
Ebrahimi, FatemehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Komeili, AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghalandari, BehafaridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghaznavi, HabibUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kamrava, S. KamranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moustakis, ChristosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-340110
DOI: 10.1016/j.ejps.2020.105235
Journal or Publication Title: Eur. J. Pharm. Sci.
Volume: 145
Date: 2020
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1879-0720
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HYPERTHERMIA; CHEMOTHERAPY; RADIOSENSITIZATION; NANOTECHNOLOGY; NANOCARRIERS; RADIOTHERAPY; RESISTANCE; RADIATION; NANORODS; PLATFORMMultiple languages
Pharmacology & PharmacyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34011

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