Universität zu Köln

Grundmann, Franziska, Mueller, Roman-Ulrich, Hoyer-Allo, Karla Johanna Ruth, Spaeth, Martin Richard, Passmann, Eva, Becker, Ingrid ORCID: 0000-0001-5829-3553, Pfister, Roman, Baldus, Stephan, Benzing, Thomas and Burst, Volker (2020). Dietary restriction for prevention of contrast-induced acute kidney injury in patients undergoing percutaneous coronary angiography: a randomized controlled trial. Sci Rep, 10 (1). LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Short-term dietary restriction (DR) may prevent organ damage from ischemic or toxic insults in animals, but clear evidence in humans is missing. While especially intraarterial administration of contrast media represents a cause of hospital-acquired acute kidney injury (AKI), targeted preventive strategies are not available. This trial investigated the feasibility and effectiveness of pre-interventional DR for preventing AKI in patients undergoing percutaneous coronary intervention (PCI). Patients were randomized to receive a formula diet containing 60% of daily energy requirement (DR group) or ad-libitum food during the 4-day-interval before PCI. Primary endpoint was change of serum creatinine 48 h after PCI (Delta creatinine). Further analyses included incidence of AKI and safety evaluation. Delta creatinine post PCI in the DR group vs. the control group did not show any difference (DR: 0.03(-0.15,0.14)mg/dL vs. control: 0.09(-0.03,0.22)mg/dL;p = 0.797). Subgroup analyses revealed a significant beneficial impact of DR in patients that received <= 100 ml of contrast agent (DR n = 26: Delta creatinine -0.03(-0.20,0.08) mg/dL vs. control n = 24: Delta creatinine 0.10(-0.08,0.24)mg/dL; p = 0.041) and in patients with <= 2 risk factors for AKI (DR: n = 27; Delta creatinine -0.01(-0.18,0.07)mg/dL vs. control n = 31: Delta creatinine 0.09(-0.03,0.16)mg/dl; p = 0.030). Although the primary endpoint was not met, the results of this trial suggest a beneficial impact of DR in low-to-moderate risk patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grundmann, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Roman-Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyer-Allo, Karla Johanna Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Spaeth, Martin Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Passmann, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Ingrid UNSPECIFIED orcid.org/0000-0001-5829-3553 UNSPECIFIED Pfister, Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Benzing, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Burst, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-340405
DOI:	10.1038/s41598-020-61895-2
Journal or Publication Title:	Sci Rep
Volume:	10
Number:	1
Date:	2020
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ISCHEMIA-REPERFUSION INJURY; INDUCED NEPHROPATHY; CALORIE RESTRICTION; RISK-FACTORS; LIFE-SPAN; PROTECTION; INTERVENTION; SIZE Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34040