Kasper, Maren, Walscheid, Karoline, Laffer, Bjoern, Bauer, Dirk, Busch, Martin, Loser, Karin, Vogl, Thomas, Langmann, Thomas, Ganser, Gerd, Rath, Thomas and Heiligenhaus, Arnd . Phenotype of Innate Immune Cells in Uveitis Associated with Axial Spondyloarthritis- and Juvenile Idiopathic Arthritis-associated Uveitis. Ocul. Immunol. Inflamm.. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1744-5078

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Abstract

Purpose: To analyze circulating immune cells in patients with anterior uveitis (AU) associated to axial spondyloarthritis (SpA), or juvenile idiopathic arthritis (JIA). Methods: Venous blood samples were collected from healthy controls (n = 16), and either SpA (n = 19) or JIA (n = 23) patients with associated anterior uveitis (AU) during active flare, or after >= 3 months of inactivity. Frequencies of CD56(+), MHC-I+, and S100A9(+) monocytes, CCR7(+) dendritic cells, CD56(+dim) natural killer (NK) cells and CD3(+)CD56(bright) T-cells were analyzed via flow cytometry. Serum S100A8/A9 levels were determined via ELISA. Results: SpA patients showed a reduced frequency of CD56(+dim) NK cells during uveitis activity, a constitutively activated monocyte phenotype, and elevated S100A8/A9 serum levels. In contrast, JIAU patients showed elevated frequencies of CD56(+) monocytes and CCR7(+) DC. Conclusion: Phenotype of peripheral immune cells differ between patients, probably contributing to different courses of acute onset AU in SpA and insidious onset AU in JIAU patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kasper, MarenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walscheid, KarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laffer, BjoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Busch, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loser, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vogl, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langmann, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ganser, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rath, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heiligenhaus, ArndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-341064
DOI: 10.1080/09273948.2020.1715449
Journal or Publication Title: Ocul. Immunol. Inflamm.
Publisher: TAYLOR & FRANCIS INC
Place of Publication: PHILADELPHIA
ISSN: 1744-5078
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANKYLOSING-SPONDYLITIS; RHEUMATOID-ARTHRITIS; DISEASE-ACTIVITY; MONOCYTE HETEROGENEITY; ANTERIOR UVEITIS; VISUAL-LOSS; ACTIVATION; CLASSIFICATION; INFLAMMATION; NOMENCLATUREMultiple languages
OphthalmologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34106

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