Humberg, Alexander, Haertel, Christoph, Rausch, Tanja K., Stichtenoth, Guido, Jung, Philipp, Wieg, Christian, Kribs, Angela, von der Wense, Axel, Weller, Ursula, Hoehn, Thomas, Olbertz, Dirk M., Felderhoff-Mueser, Ursula, Rossi, Rainer, Teig, Norbert, Heitmann, Friedhelm, Schmidtke, Susanne, Bohnhorst, Bettina, Vochem, Matthias, Segerer, Hugo, Moeller, Jens, Eichhorn, Joachim G., Wintgens, Juergen, Boettger, Ralf, Hubert, Mechthild, Doerdelmann, Michael, Hillebrand, Georg, Roll, Claudia, Jensen, Reinhard, Zemlin, Michael, Moegel, Michael, Werner, Claudius, Schaefer, Stefan, Schaible, Thomas, Franz, Axel, Heldmann, Michael, Ehlers, Silke, Kannt, Olaf, Orlikowsky, Thorsten, Gerleve, Hubert, Schneider, Katja, Haase, Roland, Boeckenholt, Kai, Linnemann, Knud, Herting, Egbert and Goepel, Wolfgang (2020). Active perinatal care of preterm infants in the German Neonatal Network. Arch. Dis. Child.-Fetal Neonatal Ed., 105 (2). S. F190 - 6. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-2052

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Abstract

Objective To determine if survival rates of preterm infants receiving active perinatal care improve over time. Design The German Neonatal Network is a cohort study of preterm infants with birth weight <1500 g. All eligible infants receiving active perinatal care are registered. We analysed data of patients discharged between 2011 and 2016. Setting 43 German level III neonatal intensive care units (NICUs). Patients 8222 preterm infants with a gestational age between 22/0 and 28/6 weeks who received active perinatal care. Interventions Participating NICUs were grouped according to their specific survival rate from 2011 to 2013 to high (percentile >P75), intermediate (P25-P75) and low (<P25) survival. We compared these survival rates with data in 2014-2016. Main outcome measures Death by any cause before discharge. Results Total survival increased from 85.8% in 2011-2013 to 87.4% in 2014-2016. This increase was due to reduced mortality of NICUs with low survival rates in 2011-2013. Survival increased in these centres from 53% to 64% in the 22-24 weeks strata and from 73% to 84% in the 25-26 weeks strata. Conclusions Our data support previous reports that active perinatal care of very immature infants improves outcomes at the border of viability and survival rates at higher gestational ages. The high total number of surviving infants below 24 weeks of gestation challenges national recommendations exclusively referring to gestational age as the single criterion for providing active care. However, more data are needed before recommendations for parental counselling should be reconsidered.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Humberg, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haertel, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rausch, Tanja K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stichtenoth, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jung, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wieg, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kribs, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von der Wense, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weller, UrsulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoehn, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olbertz, Dirk M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Felderhoff-Mueser, UrsulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rossi, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teig, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heitmann, FriedhelmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidtke, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bohnhorst, BettinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vochem, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Segerer, HugoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moeller, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eichhorn, Joachim G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wintgens, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boettger, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hubert, MechthildUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doerdelmann, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hillebrand, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roll, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jensen, ReinhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zemlin, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moegel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Werner, ClaudiusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaible, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franz, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heldmann, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ehlers, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kannt, OlafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orlikowsky, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerleve, HubertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haase, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boeckenholt, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linnemann, KnudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herting, EgbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goepel, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-341982
DOI: 10.1136/archdischild-2018-316770
Journal or Publication Title: Arch. Dis. Child.-Fetal Neonatal Ed.
Volume: 105
Number: 2
Page Range: S. F190 - 6
Date: 2020
Publisher: BMJ PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1468-2052
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
WEEKS GESTATION; SURVIVAL; OUTCOMES; BORNMultiple languages
PediatricsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34198

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