Universität zu Köln

Kreer, Christoph ORCID: 0000-0002-9140-9850, Gruell, Henning, Mora, Thierry, Walczak, Aleksandra M. and Klein, Florian (2020). Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies. Vaccines, 8 (1). BASEL: MDPI. ISSN 2076-393X

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Abstract

The human antibody repertoire is generated by the recombination of different gene segments as well as by processes of somatic mutation. Together these mechanisms result in a tremendous diversity of antibodies that are able to combat various pathogens including viruses and bacteria, or malignant cells. In this review, we summarize the opportunities and challenges that are associated with the analyses of the B cell receptor repertoire and the antigen-specific B cell response. We will discuss how recent advances have increased our understanding of the antibody response and how repertoire analyses can be exploited to inform on vaccine strategies, particularly against HIV-1.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kreer, Christoph UNSPECIFIED orcid.org/0000-0002-9140-9850 UNSPECIFIED Gruell, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Mora, Thierry UNSPECIFIED UNSPECIFIED UNSPECIFIED Walczak, Aleksandra M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-342105
DOI:	10.3390/vaccines8010013
Journal or Publication Title:	Vaccines
Volume:	8
Number:	1
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-393X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN MONOCLONAL-ANTIBODIES; POTENT NEUTRALIZING ANTIBODIES; SINGLE-CELL; GENE-SEGMENT; HIV-1-NEUTRALIZING ANTIBODIES; ZIKA VIRUS; IMMUNOGLOBULIN HEAVY; MATURATION PATHWAY; VARIABLE REGIONS; STRUCTURAL BASIS Multiple languages Immunology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34210