Universität zu Köln

Van Hedent, Steven, Tatsuoka, Curtis, Carr, Sarah ORCID: 0000-0001-6641-4415, Laukamp, Kai Roman, Eck, Brendan, Hokamp, Nils Grosse, Kessner, Rivka, Ros, Pablo and Jordan, David (2020). Impact of Patient Size and Radiation Dose on Accuracy and Precision of Iodine Quantification and Virtual Noncontrast Values in Dual-layer Detector CT-A Phantom Study. Acad. Radiol., 27 (3). S. 409 - 421. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-4046

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Abstract

Rationale and Objectives: Iodine quantification (IQ) and virtual noncontrast (VNC) images produced by dual-energy CT (DECT) can be used for various clinical applications. We investigate the performance of dual-layer DECT (DLDECT) in different phantom sizes and varying radiation doses and tube voltages, including a low-dose pediatric setting. Materials and Methods: Three phantom sizes (simulating a 10-year-old child, an average, and a large-sized adult) were scanned with iodine solution inserts with concentrations ranging 0-32 mg/ml, using the DLDECT. Each phantom size was scanned with CTDIvol 2-15 mGy at 120 and 140 kVp. The smallest phantom underwent additional scans with CTDIvol 0.9-1.8 mGy. All scans were repeated 3 times. Each iodine insert was analyzed using VNC and IQ images for accuracy and precision, by comparison to known values. Results: For scans from 2 to 15 mGy mean VNC attenuation and IQ error in the iodine inserts in the small, medium, and large phantoms was 1.2 HU +/- 3.2, -1.2 HU +/- 14.9, 2.6 HU +/- 23.6; and +0.1 mg/cc +/- 0.4, -0.9 mg/cc +/- 0.9, and -1.8 mg/cc +/- 1.8, respectively. In this dose range, there were no significant differences (p >= 0.05) in mean VNC attenuation or IQ accuracy in each phantom size, while IQ was significantly less precise in the small phantom at 2 mGy and 10 mGy (p < 0.05). Scans with CTDIvol 0.9-1.8 mGy in the small phantom showed a limited, but statistically significantly lower VNC attenuation precision and IQ accuracy (-0.5 HU +/- 5.3 and -0.3 mg/cc +/- 0.5, respectively) compared to higher dose scans in the same phantom size. Conclusion: Performance of iodine quantification and subtraction by VNC images in DLDECT is largely dose independent, with the primary factor being patient size. Low-dose pediatric scan protocols have a significant, but limited impact on IQ and VNC attenuation values.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Van Hedent, Steven UNSPECIFIED UNSPECIFIED UNSPECIFIED Tatsuoka, Curtis UNSPECIFIED UNSPECIFIED UNSPECIFIED Carr, Sarah UNSPECIFIED orcid.org/0000-0001-6641-4415 UNSPECIFIED Laukamp, Kai Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Eck, Brendan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hokamp, Nils Grosse UNSPECIFIED UNSPECIFIED UNSPECIFIED Kessner, Rivka UNSPECIFIED UNSPECIFIED UNSPECIFIED Ros, Pablo UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, David UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-342992
DOI:	10.1016/j.acra.2019.02.013
Journal or Publication Title:	Acad. Radiol.
Volume:	27
Number:	3
Page Range:	S. 409 - 421
Date:	2020
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-4046
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENERGY COMPUTED-TOMOGRAPHY; IMAGE QUALITY; INTRACRANIAL HEMORRHAGE; ITERATIVE RECONSTRUCTION; PULMONARY ANGIOGRAPHY; ATTENUATION VALUES; PERFUSION CT; CONTRAST; DIFFERENTIATION; EXPERIENCE Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34299