Siedek, Florian, Muehe, Anne M., Theruvath, Ashok J., Avedian, Raffi, Pribnow, Allison, Spunt, Sheri L., Liang, Tie, Farrell, Crystal and Daldrup-Link, Heike E. (2020). Comparison of ferumoxytol- and gadolinium chelate-enhanced MRI for assessment of sarcomas in children and adolescents. Eur. Radiol., 30 (3). S. 1790 - 1804. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

Objectives We compared the value of ferumoxytol (FMX)- and gadolinium (Gd)-enhanced MRI for assessment of sarcomas in paediatric/adolescent patients and hypothesised that tumour size and morphological features can be equally well assessed with both protocols. Methods We conducted a retrospective study of paediatric/adolescent patients with newly diagnosed bone or soft tissue sarcomas and both pre-treatment FMX- and Gd-MRI scans, which were maximal 4 weeks apart. Both protocols included T1- and T2-weighted sequences. One reader assessed tumour volumes, signal-to-noise ratios (SNR) of the primary tumour and adjacent tissues and contrast-to-noise ratios (CNR) of FMX- and Gd-MRI scans. Additionally, four readers scored FMX- and Gd-MRI scans according to 15 diagnostic parameters, using a Likert scale. The results were pooled across readers and compared between FMX- and Gd-MRI scans. Statistical methods included multivariate analyses with different models. Results Twenty-two patients met inclusion criteria (16 males, 6 females; mean age 15.3 +/- 5.0). Tumour volume was not significantly different on T1-LAVA (p = 0.721), T1-SE (p = 0.290) and T2-FSE (p = 0.609) sequences. Compared to Gd-MRI, FMX-MRI demonstrated significantly lower tumour SNR on T1-LAVA (p < 0.001), equal tumour SNR on T1-SE (p = 0.104) and T2-FSE (p = 0.305), significantly higher tumour-to-marrow CNR (p < 0.001) on T2-FSE as well as significantly higher tumour-to-liver (p = 0.021) and tumour-to-vessel (p = 0.003) CNR on T1-LAVA images. Peritumoural and marrow oedema enhanced significantly more on Gd-MRI compared to FMX-MRI (p < 0.001/p = 0.002, respectively). Tumour thrombi and neurovascular bundle involvement were assessed with a significantly higher confidence on FMX-MRI (both p < 0.001). Conclusions FMX-MRI provides equal assessment of the extent of bone and soft tissue sarcomas compared to Gd-MRI with improved tumour delineation and improved evaluation of neurovascular involvement and tumour thrombi. Therefore, FMX-MRI is a possible alternative to Gd-MRI for tumour staging in paediatric/adolescent sarcoma patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Siedek, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muehe, Anne M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Theruvath, Ashok J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Avedian, RaffiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pribnow, AllisonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spunt, Sheri L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liang, TieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farrell, CrystalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daldrup-Link, Heike E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-343149
DOI: 10.1007/s00330-019-06569-y
Journal or Publication Title: Eur. Radiol.
Volume: 30
Number: 3
Page Range: S. 1790 - 1804
Date: 2020
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-1084
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SUPERPARAMAGNETIC IRON-OXIDE; FOCAL LIVER-LESIONS; CONTRAST AGENTS; DEFICIENCY ANEMIA; GLOBUS-PALLIDUS; DENTATE NUCLEUS; BONE-MARROW; THERAPY; METASTASES; DIFFERENTIATIONMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34314

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